It is recommended to have taken and passed the modules/subjects Organic Chemistry I (Química Orgánica I) and Organic Chemistry II (Química Orgánica II).
The subject Organic Chemistry is part of the module Fundamentals of Chemistry (Fundamentos de Química) of the Chemistry Degree. The objectives of this subject are to explain concepts and basic knowledge of Organic Chemistry; to show evidence that supports those said concepts; to use them to solve chemical problems; and to prove that this subject evolves quickly and plays an important role in modern technological developments of different fields, such as biology and materials science, being a crucial part of everyday life aspects.
The natural and organic products are studied in the course ‘Ampliación de Química Orgánica’. The chemical reactions that all the living beings experiment implicate the primary metabolites of the four compounds that are essential to life: carbohydrates, lipids, proteins and nucleic acids. Nevertheless, there are other compounds that are not vital, but they usually contribute to the survival, known as secondary metabolites.
The course aims to study the reactivity of these compounds as well as to apply the previously acquired knowledge and concepts to the two main problems caused by the chemistry of natural products: the structural determination and their synthesis methods. Additionally, there will be included the isolation of natural products from an experimental point of view.
Course competences | |
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Code | Description |
CB02 | Apply their knowledge to their job or vocation in a professional manner and show that they have the competences to construct and justify arguments and solve problems within their subject area. |
E01 | Understand and use chemical terminology, nomenclature, conventions and units |
E03 | Handle chemicals safely and with respect to the environment |
E06 | Know the structural properties of chemical compounds, including stereochemistry, as well as the main structural research techniques |
E16 | Plan, design and develop projects and experiments |
G01 | Know the principles and theories of Chemistry, as well as the methodologies and applications characteristic of analytical chemistry, physical chemistry, inorganic chemistry and organic chemistry, understanding the physical and mathematical bases that require |
G02 | Be able to gather and interpret data, information and relevant results, obtain conclusions and issue reasoned reports on scientific, technological or other problems that require the use of chemical tools |
G03 | Know how to apply the theoretical-practical knowledge acquired in the different professional contexts of Chemistry |
G04 | Know how to communicate, orally and in writing, the knowledge, procedures and results of chemistry, both specialized and non-specialized |
T03 | Proper oral and written communication |
T11 | Ability to obtain bibliographic information, including Internet resources |
Course learning outcomes | |
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Description | |
Know the structure of the main organic functional groups | |
Know the structure and function of organic natural products. | |
Know the utility of the spectroscopic techniques in Organic Chemistry | |
Know the main preparation methods and the reactivity of the main organic functional groups and relate it to its structure | |
Learn to work autonomously in a laboratory and know how to interpret the experimental results obtained. | |
Recognize the main reactive intermediates and the influence of stereoelectronic effects on their stability and reactivity | |
Know how to apply the knowledge of Organic Chemistry to the solution of synthetic and structural problems | |
Know the stereochemistry of organic compounds and the stereoselectivity of the main reactions. | |
Know the basic principles of Organic Chemistry. | |
To ensure that the student is able to search and select information in the field of Organic Chemistry and that he / she is capable of processing and presenting it adequately both orally and in writing, developing his / her synthesis capacity, being critical and objective | |
To develop in the student the capacity of initiative to pose and solve concrete problems of Organic Chemistry, as well as to interpret the obtained results | |
Develop your ability to work as a team. | |
Acquire the necessary practical training to apply it in your professional life. Know the main methods of isolation, purification and characterization of organic compounds | |
Acquire the ability to handle chemical reagents and organic compounds safely. | |
Acquire an awareness of environmental protection developing the idea that Organic Chemistry should be used to improve the quality of life. | |
Encourage and promote in the student all those values ¿¿and attitudes inherent to scientific activity. | |
Know the main aspects of the terminology and nomenclature in Organic Chemistry | |
Additional outcomes | |
Not established. |
Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
Class Attendance (theory) [ON-SITE] | Lectures | E01 E06 G01 | 0.64 | 16 | N | N | ||
Class Attendance (practical) [ON-SITE] | Practical or hands-on activities | E01 E03 E06 E16 G01 T11 | 1.24 | 31 | Y | Y | Laboratory activity to acquire the practical skills and competences included in the subject. | |
Workshops or seminars [ON-SITE] | Problem solving and exercises | CB02 E01 E06 G02 G03 G04 | 0.32 | 8 | Y | N | ||
Group tutoring sessions [ON-SITE] | Combination of methods | CB02 E01 E06 G02 G03 G04 | 0.04 | 1 | Y | N | ||
Study and Exam Preparation [OFF-SITE] | Self-study | G02 T11 | 2.8 | 70 | N | N | ||
Other off-site activity [OFF-SITE] | Problem solving and exercises | G02 T11 | 0.8 | 20 | N | N | ||
Progress test [ON-SITE] | Combination of methods | CB02 E16 G02 G03 G04 T03 | 0.08 | 2 | Y | N | ||
Final test [ON-SITE] | Combination of methods | CB02 E16 G02 G03 G04 T03 | 0.08 | 2 | Y | Y | Learning activity in which the student must demonstrate the level of achievement of the competences included in the subject. | |
Total: | 6 | 150 | ||||||
Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
Total credits of out of class work: 3.6 | Total hours of out of class work: 90 |
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
Assessment of problem solving and/or case studies | 10.00% | 0.00% | It will be positively evaluated the resolution of problems/exercises as well as in class participation. In addition, the student may increase their final grade by completing the exercises handed over by the professor. |
Progress Tests | 65.00% | 0.00% | There will be two 2-hours mid-terms to evaluate the learning of the student. |
Laboratory sessions | 25.00% | 25.00% | The practical credits will be marked together during the diary lab work where there will be taken into account several aspects, such as dexterity, order, capacity for initiative¿ Additionally, there will be two exercises related to the practices in the final exam. |
Final test | 0.00% | 75.00% | There will be a final exam of the module. Nonetheless, the students that have passed the mid-terms would be able to avoid taking this final test. |
Total: | 100.00% | 100.00% |
Not related to the syllabus/contents | |
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Hours | hours |
Class Attendance (practical) [PRESENCIAL][Practical or hands-on activities] | 31 |
Study and Exam Preparation [AUTÓNOMA][Self-study] | 70 |
Other off-site activity [AUTÓNOMA][Problem solving and exercises] | 20 |
Progress test [PRESENCIAL][Combination of methods] | 2 |
Final test [PRESENCIAL][Combination of methods] | 2 |
Unit 1 (de 4): AMINO ACIDS, PEPTIDES AND PROTEINS: Classification. Stereochemistry. Acid-base behavior. Isoelectric point. Analysis of amino acids. Synthesis methods. Enantioselective synthesis. Peptides. Determination of peptide structure: amino acid analysis. Sequence analysis. Analysis of terminal groups: N-terminal and C-terminal. Selective hydrolysis of peptides. Peptide synthesis strategy. Protection of the amino group. Protection of the carboxyl group. Activation and coupling. Peptide bonds formation. Peptides synthesis in solid phase. Merrifield method. Secondary structure of peptides and proteins. Tertiary structure. Coenzymes. Quaternary structure of proteins. Hemoglobin. | |
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Activities | Hours |
Class Attendance (theory) [PRESENCIAL][Lectures] | 5 |
Workshops or seminars [PRESENCIAL][Problem solving and exercises] | 2 |
Unit 2 (de 4): CARBOHYDRATES AND NUCLEIC ACIDS: Introduction. Classification. Fischer projections. D-L notation system. Aldoses and ketoses. Rosanoff classification. Cyclic forms: Furanoses, pyranoses. Mutarotation. Anomeric effect. Glycosides. Disaccharides. Polysaccharides. Cell surface glycoproteins. Reactivity of monosaccharides. Reaction with phenylhydrazine. Reduction. Oxidation. Reactions of epimerization, isomerization and retroaldol degradation. Reaction with acid. Formation of thioacetals. Reaction with carbonyl compounds. Chain extension. Aldose degradation reactions. Nucleic acids: nucleosides, nucleotides, nucleic acids. | |
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Activities | Hours |
Class Attendance (theory) [PRESENCIAL][Lectures] | 6 |
Workshops or seminars [PRESENCIAL][Problem solving and exercises] | 2 |
Group tutoring sessions [PRESENCIAL][Combination of methods] | 1 |
Unit 3 (de 4): METABOLITES DERIVED FROM ACETATE: Acetylcoenzyme A. Fatty acids, fats and waxes. Biosynthesis of fatty acids. Phospholipids. Prostaglandins. Thromboxanes. Leukotrienes. Terpenes. Isoprene rule and classification of terpenes. Biosynthesis of terpenes. Mevalonic acid route. Linear, monocyclic and bicyclic terpenes. Steroids: structure. Biosynthesis of cholesterol. Carotenoids: structure. Chemistry of vision. | |
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Activities | Hours |
Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
Workshops or seminars [PRESENCIAL][Problem solving and exercises] | 2 |
Unit 4 (de 4): OTHER SECONDARY METABOLITES: Polyphenols. Shikimic acid route. Galotanines. Hydroxycinnamic acids. Coumarins. Polyketides route. Naphthoquinones. Anthraquinones. Tetracyclines. Flavonoids. Isoflavonoids. Alkaloids. Alkaloids derived from ornithine and lysine. Alkaloids with pyrrolidine and piperidine structure. Alkaloids with pyrrolizidine and quinolizidine structure. Alkaloids with pyridine structure. Alkaloids derived from phenylalanine and tyrosine. Alkaloids derived from tryptophan: indole alkaloids. Alkaloids derived from purines. | |
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Activities | Hours |
Class Attendance (theory) [PRESENCIAL][Lectures] | 2 |
Workshops or seminars [PRESENCIAL][Problem solving and exercises] | 2 |
Global activity | |
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Activities | hours |