1. General information
Course:
TOXICOLOGY
Code:
14335
Type:
CORE COURSE
ECTS credits:
6
Degree:
376 - UNDERGRADUATE DEGREE PROGRAMME IN PHARMACY
Academic year:
2023-24
Center:
14 - FACULTY OF PHARMACY
Group(s):
10
Year:
4
Duration:
C2
Main language:
Spanish
Second language:
English
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
CARLOS ALONSO MORENO
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
FACULTAD DE FARMACIA
QUÍMICA INORG., ORG., Y BIOQ.
8237
carlos.amoreno@uclm.es
Mondays and Wednesdays from 16-19h. Must be requested in advance by e-mail.
Lecturer:
Mª DEL MAR ARROYO JIMENEZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia. Área de Anatomía.
CIENCIAS MÉDICAS
8249
mariamar.arroyo@uclm.es
Tuesdays and Thursday from 16-19h. Must be requested in advance by e-mail.
Lecturer:
ELENA CALVO LEJARRAGA
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
CIENCIAS MÉDICAS
Elena.Calvo@uclm.es
Lecturer:
FELIPE DE LA CRUZ MARTÍNEZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
FACULTAD DE FARMACIA
QUÍMICA INORG., ORG., Y BIOQ.
Felipe.Cruz@uclm.es
Tuesdays and Thursday from 16-19h. Must be requested in advance by e-mail.
Lecturer:
NOEMÍ VILLASECA GONZÁLEZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia
CIENCIAS MÉDICAS
Noemi.VGonzalez@uclm.es
Mondays and Wednesdays from 16-19h. Must be requested in advance by e-mail.
2. Pre-Requisites
There are no prerequisites to take this course, although it is recommended that the student has passed the courses of Chemistry, Anatomy, Biochemistry, Physiology, Physiopathology, General Pharmacology, Biopharmacology and Pharmacokinetics.
3. Justification in the curriculum, relation to other subjects and to the profession
Toxicology is a subject of the fourth year of the Degree of Pharmacy at the University of Castilla-La Mancha. This subject has a total of 6 ECTS credits and is taught every semester. The main objective is the toxicological training that allows the interpretation of scientific data related to xenobiotics. To this end, students will be provided with the necessary knowledge on basic toxicology, classification of toxic substances, mechanisms of toxicity, evaluation of toxicity, pathologies generated, and therapy. Likewise, the student will acquire knowledge about the methodologies that allow deduction of toxic concentrations in biological samples. ed
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| B01 | Proficiency in a second foreign language at level B1 of the Common European Framework of Reference for Languages. |
| B02 | Knowledge of Information and Communication Technologies (ICT). |
| B03 | A correct oral and written communication |
| B04 | Ethical commitment and professional deontology. |
| B05 | Ability to develop those learning skills necessary to undertake further studies. |
| EM02 | Know and fully understand the basic fundamentals of clinical analysis, as well as the characteristics and contents of the laboratory diagnosis specifications |
| EM05 | Know and understand the techniques used in the design and evaluation of pre-clinical and clinical trials. |
| EM07 | Promote the rational use of medicines and health products. |
| EM11 | Assess the toxicological effects of substances. Design and apply the corresponding tests and analysis. |
| EM13 | Know and understand the structure and function of the human body, as well as the general mechanisms of disease, molecular, structural and functional alterations, syndromic expression and therapeutic tools to restore health. |
| EM14 | Know the nature, mechanism of action and effect of the xenobiotics, as well as the protocols of action in case of poisoning |
| EM15 | Know the analytical techniques related to laboratory diagnosis, toxic, food and environment determinations. |
| EM16 | Know and fully understand the managements and characteristics of pharmaceutical assistance in the field of office and the pharmaceutical industry |
| G01 | Identify, design, obtain, analyze, control and produce drugs and medicines, as well as other products and raw materials of sanitary interest for human or veterinary use. |
| G02 | Evaluate the therapeutic and toxic effects of substances with pharmacological activity. |
| G03 | Know how to apply the scientific method and acquire skills in the handling of legislation, sources of information, bibliography, elaboration of protocols and other aspects considered necessary for the design and critical evaluation of preclinical and clinical trials. |
| G04 | Design, prepare, supply and dispense medicines and other products of health interest. |
| G05 | Provide therapeutic advice in pharmacotherapy and dietotherapy, as well as in the nutritional and food field in the establishments where they provide services. |
| G06 | Promote the rational use of medicines and medical devices, as well as to acquire basic knowledge in clinical management, health economics and the efficient use of health resources. |
| G07 | Identify, evaluate and assess problems related to drugs and medicines, as well as participate in pharmacovigilance activities. |
| G08 | Conducting clinical and social pharmacy activities, following the pharmaceutical care cycle. |
| G09 | Intervene in health promotion and disease prevention activities at the individual, family and community levels, with an integral and multi-professional vision of the health-disease process. |
| G10 | Design, apply and evaluate clinical reagents, methods and analytical techniques, knowing the basic principles of clinical analysis and the characteristics and contents of laboratory diagnostic reports. |
| G11 | Evaluate the toxicological effects of substances and design and apply appropriate tests and trials. |
| G12 | Develop hygienic-sanitary analyses, especially those related to food and environment. |
| G13 | Develop communication and information skills, both oral and written, to deal with patients and users of the centre where they carry out their professional activity. Promote the capacity to work and collaborate with multidisciplinary teams and those related to other health professionals. |
| G14 | Know the ethical and deontological principles according to the legislative, regulatory and administrative provisions governing professional practice, understanding the ethical implications of health in a changing social context. |
| G15 | Recognise own limitations and the need to maintain and update professional competence, with particular emphasis on self-learning of new knowledge based on scientific evidence. |
| T01 | Critical thinking skills based on the application of the scientific method |
| T02 | Ability to manage quality scientific information, bibliography, specialized databases and resources accessible through the Internet. |
| T03 | Handling of basic and specific software for the treatment of information and experimental results. |
| T04 | Motivation for quality, safety at work and awareness of environmental issues, with knowledge of the internationally recognised systems for the correct management of these aspects. |
| T05 | Organizational, planning and implementation skills. |
| T06 | Ability to address human resources decision-making and management. |
| T07 | Ability to work as a team and, where appropriate, exercise leadership functions, encouraging entrepreneurship. |
| T08 | Develop interpersonal skills and the ability to function in an international and multicultural context. |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| To know the basic biomarkers of toxicity. | |
| Understand the important current challenges of toxicology in the evaluation of the safety of medicines, household products and the effects of accidental and occupational exposure to natural and synthetic substances. | |
| To know the bases of the general etiology of the most common poisonings and the treatment. | |
| Know and understand the fundamentals of Toxicology. | |
| Identify the toxic effects of exposure to different toxic substances. | |
| Identify the toxic effects derived from the consumption of drugs and drugs of abuse. | |
| Know how to make an expert report on the safety of a medicinal product. | |
| Know how to use the fundamental techniques and methods for toxicological research (sampling, laboratory diagnosis, toxics, food and environment). | |
| Develop risk assessment to prevent and treat poisonings. | |
| Develop the best treatments in the event of poisoning from an overdose or prolonged use of a drug or non-therapeutic agent. | |
| Know how to communicate results and conclusions. | |
| Know how to determine the range of exposure that is safe and the level of exposure that can be hazardous to human health and the environment of a medicinal product or non-therapeutic chemical agent. | |
| Know how to design protocols for toxicity testing in experimental animals to ensure the short- and long-term safety of drugs or other products before they are placed on the market. | |
| Know how to interpret the results of in vivo and in vitro toxicity tests in the evaluation of a new medicinal product. | |
| Additional outcomes | |
| Not established. |
6. Units / Contents
-
Unit 1: Introduction to toxicology. Historical evolutio
-
Unit 2: Introduction to toxicology. Systemic toxicology
-
Unit 3: Toxic substances. Metals.
-
Unit 4: Toxic substances. Radioactive wastes and atmospheric pollutants.
-
Unit 5: Toxic substances. Agrochemicals
-
Unit 6: Toxic substances. Solvents and vapors
-
Unit 7: Toxic substances. Chemical-toxicological analysis
-
Unit 8: Systemic toxicology. Neurotoxicity
-
Unit 9: Systemic toxicology. Hepatotoxicity
-
Unit 10: Systemic toxicology. Nephrotoxicity
-
Unit 11: Systemic toxicology. Other types of toxicity
-
Unit 12: Applied toxicology. Food, regulatory, forensic and clinical toxicology. Internships
ADDITIONAL COMMENTS, REMARKS
1. Buscatox
2. Determination of benzodiazepines by liquid chromatography in biological samples.
3. Determination of alcohol by gas chromatography in biological samples.
4. Determination of acetylcholinesterase.
5. Preparation of the toxicological report.
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Lectures | B01 B02 B03 B04 B05 EM02 EM05 EM07 EM11 EM13 EM14 EM15 EM16 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 1.14 | 28.5 | Y | N | Teaching resources will be available on the Moodle platform before the beginning of the activities. In addition, students will have access to complementary bibliographic and audiovisual material (books, review articles, videos) in the university library of the Albacete campus. | |
| Class Attendance (practical) [ON-SITE] | Practical or hands-on activities | B01 B02 B03 B04 B05 EM02 EM05 EM07 EM11 EM13 EM14 EM15 EM16 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.8 | 20 | Y | Y | Practical teaching will be given in small groups within periods established in the academic calendar that do not coincide with other teaching activities of the course. They will be carried out in classrooms and/or laboratories. These activities are MANDATORY, so that the student will not be able to pass the course if they are not carried out properly. | |
| Formative Assessment [ON-SITE] | Assessment tests | B01 B02 B03 B04 B05 EM02 EM05 EM07 EM11 EM13 EM14 EM15 EM16 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.16 | 4 | Y | Y | The student may request personal tutoring on the contents of the course by previously arranging an interview with the corresponding professor. | |
| Study and Exam Preparation [OFF-SITE] | Self-study | B01 B02 B03 B04 B05 EM02 EM05 EM07 EM11 EM13 EM14 EM15 EM16 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 3.6 | 90 | Y | N | The student may request tutorials by e-mail or in person. | |
| Project or Topic Presentations [ON-SITE] | project-based learning | B01 B02 B03 B04 B05 EM02 EM05 EM07 EM11 EM13 EM14 EM15 EM16 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.3 | 7.5 | Y | N | The active participation of the student will be assessed through the defense of the work called: "Apadrina". In addition, the active participation of the student will be valued during the last 5 sessions destined for the oral presentation and that will be taken into account in the final evaluation. | |
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Test | 70.00% | 70.00% | Theoretical knowledge is evaluated, as well as its application to the resolution of problems and practical cases. |
| Laboratory sessions | 10.00% | 10.00% | Attendance in the practical classes is mandatory. The practices are mandatory activities, so the existence of an absence without proper justification, will mean that the student CAN NOT pass the course in the ordinary call. The grade obtained will represent 10% of the final grade of the course. In case the student does not pass the practical block in the ordinary exam, he/she will have another opportunity in the final exam of the extraordinary exam to pass the subject. Once the practical block has been passed, the grade obtained will be retained for the following two academic years. Students who do not pass the practical block due to unjustified lack of attendance will be evaluated in the extraordinary exam by means of a specific test in which they must demonstrate that they have achieved the practical competencies. |
| Theoretical papers assessment | 20.00% | 20.00% | The professors advise the student to regularly attend classroom activities during the course. Attendance, presentation and public defence of the work "apadrina" will be valued at 20% of the final grade of the course, which will take place during the last 5 classroom sessions that are included in the academic calendar. |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:EVALUATION OF THE THEORETICAL PART
70% of the final grade. It will consist of 1 TEST in the middle of the semester and 1 FINAL TEST (35% of the final grade each).
The partial test will have a value of 35% of the final grade. The student must know that in order to put away the subject, the grade of each of the tests must be equal to or higher than 4.
PRACTICAL PART EVALUATION
10% of the final grade. Attendance in the practical module is MANDATORY. Once the practical module has been passed, the grade obtained during the internship will be kept for the following two academic years. To pass the practical part, the student must obtain AT LEAST 4 points. In order to keep the practical grade for the following academic year, it must be equal to or higher than 5.0.
EVALUATION OF ACTIVITIES MODULE:
20% of the final grade. Its evaluation will be in the classroom through the preparation of an original work called "apadrina" c, which will be defended in public on the dates that will be indicated in due course. The attendance and active participation of the student in the 5 sessions scheduled in the calendar for the presentation of this activity will be taken into account.
Students who cannot perform this activity in person for justified reasons may request the teacher to perform a non-face-to-face activity of which they will be evaluated.
In order to keep the grade of the activity module for the following course, it must be equal to or higher than 5.0.
The course will be passed when the student obtains AT LEAST 5 POINTS in the overall grade. -
Non-continuous evaluation:VALUATION THEORETICAL PART
70% of the final grade. It will consist of a FINAL TEST that may include theoretical concepts, practical cases, problems, etc. In order to pass the theoretical content part, the student must obtain AT LEAST 4 POINTS in this test.
EVALUATION OF THE PRACTICAL PART
10% of the final grade. For those students who have failed the practical part, they will be able to take an exam of practical knowledge in the EXTRAORDINARY CALL. A grade of AT LEAST 4 POINTS is required to pass the practical part.
The student will have to pass independently each of the two parts (theory and practice) to pass the course so that if he/she has passed any of the parts in the ordinary exam it is not necessary to take the extraordinary exam.
In the event that only the practical part is passed, the grade obtained in this part will be retained for the following two academic years. However, if the part that is passed is the theoretical one and not the practical one, the course will be considered failed for both parts (theoretical and practical). In order to keep the practical grade for the following academic year, it must be equal to or higher than 5.0.
EVALUATION OF THE ACTIVITIES PART
The remaining 20% of the grade corresponds to the participation activities proposed throughout the course. Students who cannot perform these activities in person for justified reasons may request the teacher to perform a non-face-to-face activity for which they will be evaluated. In order to keep the practical grade for the following course, it must be equal to or higher than 5.0. The course will be passed when the student obtains AT LEAST 5 POINTS in the overall grade.
Specifications for the resit/retake exam:
The course will be passed when the student obtains AT LEAST 5 POINTS in the overall grade and HAS PREVIOUSLY pass D THE THEORETICAL AND PRACTICAL PART.
EVALUATION OF THE THEORETICAL PART
70% of the final grade. It will consist of a FINAL TEST that may include theoretical concepts, practical cases, problems, etc. In order to pass the theoretical content part, the student must obtain AT LEAST 4 POINTS in this test.
EVALUATION OF THE PRACTICAL MODULE
10% of the final grade. For those students who have failed the practical module, they will be able to take an exam of practical knowledge in the EXTRAORDINARY CALL. A grade of AT LEAST 4 POINTS is required to pass the practical module. In order to keep the practical grade for the following course, it must be equal or higher than 5.0.
EVALUATION OF ACTIVITIES MODULE
20% of the final grade. The possibility of recovering the activities part is not taken into consideration, so the grade obtained during the regular exam will be maintained.
The grade may be kept during the following two academic years, if the student so declares, as long as it is equal to or higher than 5.0.
EVALUATION OF THE THEORETICAL PART
70% of the final grade. It will consist of a FINAL TEST that may include theoretical concepts, practical cases, problems, etc. In order to pass the theoretical content part, the student must obtain AT LEAST 4 POINTS in this test.
EVALUATION OF THE PRACTICAL MODULE
10% of the final grade. For those students who have failed the practical module, they will be able to take an exam of practical knowledge in the EXTRAORDINARY CALL. A grade of AT LEAST 4 POINTS is required to pass the practical module. In order to keep the practical grade for the following course, it must be equal or higher than 5.0.
EVALUATION OF ACTIVITIES MODULE
20% of the final grade. The possibility of recovering the activities part is not taken into consideration, so the grade obtained during the regular exam will be maintained.
The grade may be kept during the following two academic years, if the student so declares, as long as it is equal to or higher than 5.0.
Specifications for the second resit / retake exam:
Only students who meet the requirements set forth in the Student Evaluation Regulations of the University of Castilla-La Mancha will be eligible for this call and will be evaluated according to the criteria applied in the extraordinary call.
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 36 |
| Class Attendance (practical) [PRESENCIAL][Practical or hands-on activities] | 20 |
| Formative Assessment [PRESENCIAL][Assessment tests] | 90 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 4 |
| Global activity | |
|---|---|
| Activities | hours |
10. Bibliography and Sources