1. General information
Course:
PHARMACEUTICAL TECHNOLOGY II
Code:
14330
Type:
CORE COURSE
ECTS credits:
6
Degree:
376 - UNDERGRADUATE DEGREE PROGRAMME IN PHARMACY
Academic year:
2023-24
Center:
14 - FACULTY OF PHARMACY
Group(s):
10
Year:
4
Duration:
First semester
Main language:
Spanish
Second language:
English
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
MARIA FRANCISCA GALINDO ANAYA
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia 2.17
CIENCIAS MÉDICAS
967599200
maria.galindo@uclm.es
Mondays and Wednesdays from 16:00-19:00
Make an appointment in advance by email
Lecturer:
JOAQUIN GONZALEZ FUENTES
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia AB. Despecho 3.8
CIENCIAS MÉDICAS
2236
joaquin.gfuentes@uclm.es
Mondays and Wednesdays from 16:00-19:00
Make an appointment in advance by email
Lecturer:
MARIA VICTORIA LOZANO LOPEZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad Farmacia. 2.4
CIENCIAS MÉDICAS
8238
mvictoria.lozano@uclm.es
Mondays and Wednesdays from 16:00-19:00
Make an appointment in advance by email
2. Pre-Requisites
There are no prerequisites but it is recommended:
Basic training in Physics and Chemistry to know the characteristics and properties of chemical products, bases of the physical and physicochemical processes necessary in the sequence of operations for the manufacture and control of medicinal products. Statistical training involved in the manufacture of medicines.
Basic training in Physiology and Pharmacology for knowledge of the place and form of action of drugs in order to choose the appropriate route of administration and pharmaceutical form for each active ingredient.
3. Justification in the curriculum, relation to other subjects and to the profession
Pharmaceutical Technology is the discipline of the Pharmacy degree that provides the scientific and technological knowledge involved in the design, preparation and evaluation of the dosage forms of medicines. This knowledge enables the pharmacist to provide information, care and advice to patients on the administration and conservation of medicines.
All these characteristics are related to subjects such as Biopharmacy and Pharmacokinetics, Pharmaceutical Technology I and III, leading the student to acquire the necessary training to successfully deal with the administration of drugs with effective, safe and stable dosage forms.
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| B01 | Proficiency in a second foreign language at level B1 of the Common European Framework of Reference for Languages. |
| B02 | Knowledge of Information and Communication Technologies (ICT). |
| B03 | A correct oral and written communication |
| B04 | Ethical commitment and professional deontology. |
| B05 | Ability to develop those learning skills necessary to undertake further studies. |
| EFT01 | Using statistical analysis applied to pharmaceutical sciences |
| EFT02 | Apply both computational and data processing techniques, for getting information about physical, chemical and biological data |
| EFT05 | Using statistical analysis applied to pharmaceutical sciences |
| EFT06 | Design, optimize and elaborate the pharmaceutical forms guaranteeing their quality, including the formulation and quality control of medicines, the development of master formulas and officinal preparations. |
| EFT07 | Able to apply the quality control process to medical devices, dermopharmaceutical and cosmetic products and package materials. |
| G01 | Identify, design, obtain, analyze, control and produce drugs and medicines, as well as other products and raw materials of sanitary interest for human or veterinary use. |
| G04 | Design, prepare, supply and dispense medicines and other products of health interest. |
| G13 | Develop communication and information skills, both oral and written, to deal with patients and users of the centre where they carry out their professional activity. Promote the capacity to work and collaborate with multidisciplinary teams and those related to other health professionals. |
| G15 | Recognise own limitations and the need to maintain and update professional competence, with particular emphasis on self-learning of new knowledge based on scientific evidence. |
| T01 | Critical thinking skills based on the application of the scientific method |
| T02 | Ability to manage quality scientific information, bibliography, specialized databases and resources accessible through the Internet. |
| T03 | Handling of basic and specific software for the treatment of information and experimental results. |
| T04 | Motivation for quality, safety at work and awareness of environmental issues, with knowledge of the internationally recognised systems for the correct management of these aspects. |
| T05 | Organizational, planning and implementation skills. |
| T06 | Ability to address human resources decision-making and management. |
| T07 | Ability to work as a team and, where appropriate, exercise leadership functions, encouraging entrepreneurship. |
| T08 | Develop interpersonal skills and the ability to function in an international and multicultural context. |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| To know the controls in raw materials, semi-finished and finished products, as well as the validation of processes in order to ensure the quality of the medicines manufactured. | |
| Understanding the checks necessary to ensure the quality of pharmaceutics skin products, sanitary products, and cosmetics. | |
| Ability to select the route of administration and the pharmaceutical form. | |
| Ability to work under standards of good laboratory practice (GLP). | |
| Ability to plan, design and develop preformulation studies of the different pharmaceutical forms and to interpret the results. | |
| Know the vehiculizacion nanoparticles as forms of drugs. | |
| Know and understand the fundamentals of the Pharmaceutical Technology | |
| Develop drugs regarding its qualitative and quantitative composition and select the optimal technological processes to be used in its manufacture. | |
| Additional outcomes | |
| Not established. |
6. Units / Contents
-
Unit 1: COLLOIDAL SYSTEMS AS DRUG VECTORS.
-
Unit 1.1: Objectives and classification. Obtaining methods. Liposomes. Microspheres. Microparticles. Nanoparticles. Nanocapsules.
-
Unit 1.2: Colloidal systems for topical administration. Colloidal systems for mucosal administration. Colloidal systems for parenteral parenteral administration.
-
-
Unit 2: PHARMACEUTICAL FORMS FOR PARENTERAL ADMINISTRATION
-
Unit 2.1: Parenteral administration forms I: Classification. Requirements. Sterilisation and depyrogenation methods. Methods of isotonisation.
-
Unit 2.2: Parenteral dosage forms II: Preparation of parenteral dosage forms. Vehicles and additives. Packaging and conditioning. Testing and controls. Seminar on isotony.
-
-
Unit 3: PHARMACEUTICAL FORMS FOR PULMONARY ADMINISTRATION. OPERATIONS AND TECHNOLOGICAL PROCESSES RELATED TO THEIR MANUFACTURING. EXCIPIENTS AND QUALITY CONTROL
-
Unit 3.1: Aerosols. Basic biopharmaceutical and technological requirements. Devices: pressurised canisters, dry powder inhalers and nebulisers. nebulisers. Technological processes for their manufacture. Quality control
-
-
Unit 4: PHARMACEUTICAL FORMS AND MANUFACTURING PROCESSES FOR MEDICINAL PRODUCTS FOR SKIN AND MUCOSAL ADMINISTRATION
-
Unit 4.1: Pharmaceutical forms for cutaneous application. Semi-solid forms. Classification. Technological processes for their manufacture. Quality control. quality control.
-
Unit 4.2: Pharmaceutical forms for ocular administration. Eye drops. Ophthalmic semi-solid forms.
-
Unit 4.3: Pharmaceutical forms for nasal and otic administration.
-
Unit 4.4: Pharmaceutical forms for rectal administration.
-
Unit 4.5: Pharmaceutical forms for vaginal administration.
-
-
Unit 5: MODIFIED-RELEASE MEDICINES.
-
Unit 5.1: Controlled release systems.Definition, classification and release mechanisms.
-
Unit 5.2: Modified release oral dosage forms.Osmotic systems.Matrix systems. Other systems. Preparation procedures. Preparation procedures.excipients and adjuvants Quality control.
-
Unit 5.3: Modified-release parenteral dosage forms. Liquid systems and implants. Biocompatible, bioerosionable and biodegradable systems. biodegradable systems. Preparation procedures. Quality control.
-
Unit 5.4: Transdermal systems. Classification. Technological processes for their elaboration. Quality control.
-
Unit 5.5: Modified release systems for other routes. Classification. Basic biopharmaceutical and technological requirements. Vehicles and additives. Quality control.
-
-
Unit 6: GALENIC DEVELOPMENT. STAGES IN THE DEVELOPMENT OF A MEDICINAL PRODUCT. PREFORMULATION, FORMULATION AND STABILITY OF MEDICINAL PRODUCTS.
-
Unit 6.1: Concepts and phases of galenic development.
-
Unit 6.2: Preformulation I. Objectives.Technological aspects.Physical and physico-chemical characterisation.Compatibility studies.Protein and peptide activeprotein and peptide nature.
-
Unit 6.3: Preformulation II: Biopharmaceutical aspects.In vitro studies. In vivo studies. Conclusions.
-
Unit 6.4: Formulation. Design and optimisation of the formulation phase.
-
Unit 6.5: Stability in solution.Kinetics of degradation processes. Transition state theory. Influence of temperature: activation energy. energy.Accelerated stability studies. Influence of pH, polarity and ionic strength of the medium. Drug degradation mechanisms. Stabilisation procedures.
-
Unit 6.6: Stability in the solid state. Kinetics of degradation processes. Biopharmaceutical shelf life. ICH regulations.
-
ADDITIONAL COMMENTS, REMARKS
PRACTICE SCRIPT
- Formulation of colloidal systems.
- Stability of colloidal systems.
- Dissolution study of controlled release forms.
- Pharmaceutical forms for cutaneous application.
- Stability of drugs in solution.
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Combination of methods | B01 B02 B03 B04 B05 EFT01 EFT02 EFT05 EFT06 EFT07 G01 G04 G13 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 1.44 | 36 | Y | N | The availability of teaching resources will be accessible on the Moodle platform before starting the activities. In addition, students will have access to complementary bibliographic and audiovisual material (books, review articles, videos) in the university library on the Albacete campus. The teaching methodology through a combination of methods will include the expository/lecture method together with case studies. The active student participation in face-to-face teaching in workshops and seminars will be assessed using ICT tools. Cooperative work both in the classroom and outside of it will be materialised in the preparation and defence of work, as well as in the resolution of problems and/or cases that will be oral presentations. The grades obtained in these activities will be considered for the final assessment of the course. | |
| Class Attendance (practical) [ON-SITE] | Practical or hands-on activities | B01 B02 B03 B04 B05 EFT01 EFT02 EFT05 EFT06 EFT07 G01 G04 G13 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.8 | 20 | Y | Y | Practical teaching will be given in small groups within the periods established in the academic calendar, which do not coincide with other teaching activities. It will take place in classrooms and/or laboratories, equipped with the appropriate means to achieve the proposed objectives. They are COMPULSORY activities, so the student will not be able to pass the the course if they are not properly done. | |
| Formative Assessment [ON-SITE] | Assessment tests | B01 B02 B03 B04 B05 EFT01 EFT02 EFT05 EFT06 EFT07 G01 G04 G13 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.16 | 4 | Y | Y | Specific dates have been set in the academic calendar for the assessment tests that do not coincide with other teaching activities. | |
| Study and Exam Preparation [OFF-SITE] | Self-study | B01 B02 B03 B04 B05 EFT01 EFT02 EFT05 EFT06 EFT07 G01 G04 G13 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 3.6 | 90 | Y | N | Students may request personal tutorials on the contents of the subject by previously arranging the interview with the corresponding teacher. | |
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Test | 70.00% | 70.00% | Theoretical knowledge is assessed, as well as its application to the resolution of problems and case studies. |
| Laboratory sessions | 20.00% | 20.00% | Attendance to the practical laboratory classes is compulsory. The grade obtained will account for 20 % of the final grade of the course. The application in the laboratory work of the knowledge previously learnt, the student's attitude and the adequate individual preparation of the laboratory notebook will also be considered. The laboratory notebook will be will be graded as PASS/FAIL. It is essential to obtain a PASS grade in the laboratory workbook to pass the practical section of the course, whose final grade will be the one obtained in the practical exam. If the student does not pass the practical section in the ordinary exam, he/she will have another opportunity to pass the course in the final exam of the extraordinary call. Once the practical section has been passed, the grade obtained will be kept for the following two academic years. |
| Assessment of active participation | 10.00% | 10.00% | The teacher suggests that the student should attend regularly to the face-to-face activities during the course. The development of questions and problems by the student will be favourably assessed, as well as the presentation and public defence of works, the student's active participation and his/her attitude in class and tutorials. These activities are not compulsory. |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:In this modality, the subject will follow a continuous evaluation system, adapted to the regulatory norms of the University of Castilla-La Mancha.
The final grade will take into account, proportionally, the average of the written tests (70%), the completion of laboratory practices (20%)
and participation in seminars or other activities proposed in class (10%).
It will be assumed that all students opt for the continuous modality, unless otherwise informed (non-continuous modality) by means of a
email addressed to the professor responsible for the subject until 50% of all the evaluable activities have been completed or the
class period has ended.
The subject will be passed as long as a final average grade equal to or greater than 5 out of 10 is obtained among the different blocks (Theoretical, Practical and
Stake). It will be possible to add the marks obtained from the Theoretical and Practical block from a mark of 4 out of 10.
THEORETICAL MODULE EVALUATION (70% of the final mark). It will consist of a partial test (continuous assessment) and a final test. Both may
include theoretical concepts, topics covered in practices or in different teaching activities, problems or clinical cases, etc. The student who
pass a 4 in the partial test, you can decide whether to take an exam for the entire subject, or eliminate the contents corresponding to the partial test
to the final test, in this case each test will have a value of 50%. This decision will have to be notified to the professor responsible for the subject via
email at least 2 weeks before the date of the second final test. In order to be able to add the note corresponding to the theoretical block
of the subject through continuous evaluation, a minimum grade of 4 must be obtained in each of the tests.
PRACTICAL MODULE EVALUATION (20% of the final mark). Attendance at practices is MANDATORY. It will be evaluated by presenting a
laboratory notebook and a knowledge test, although the attitude in the laboratory, compliance with safety regulations and management of
residues may also be considered in the qualification. To pass the practical module, a qualification of AT LEAST 5 POINTS must be obtained in order to keep it for the following two academic years. The
The grade may be kept for the following two academic years, if the student so states in writing to the responsible professor. For
To be able to choose to add the grade from the practical block to the rest of the blocks, a minimum grade of 4 must be obtained in this block of the subject.
EVALUATION OF THE ACTIVITIES MODULE (10% of the final mark). Its evaluation will be in the classroom by carrying out the proposed activities
by the teacher. They are NON-MANDATORY. It will only be taken into account once the theoretical-practical block has been passed. The rating can be
retain it for the next two academic years, if the student states so in writing to the responsible professor. If a student could not
carry out any of the evaluable activities of the block of activities in person, for justified reasons, you can ask the teacher for the
carrying out another non-contact activity, of which they will be evaluated, to achieve the competencies.
In the event that the student does not reach the grade required to pass the ordinary call, and has to take the extraordinary one, the qualification of the
Theoretical and practical blocks can only be retained if a minimum score of 4 points has been reached. The activity note is not subject to this rule.
It is recalled that the material prepared by the teacher and made available to students on the Virtual Campus platform is the property of the teacher,
so taking it out of that context and making it available to people outside that platform will be considered plagiarism. Likewise, carrying out
different tests with unauthorized aid or material will be considered fraud. In accordance with the provisions of the Evaluation Regulation of the
student, the test in which fraud has been detected will be considered invalid and will be graded with fail (0), including as a fraudulent act
any type of plagiarism detected. -
Non-continuous evaluation:The subject can follow a non-continuous evaluation system, adapted to the regulatory norms of the University of Castilla-La Mancha.
The final grade will take into account, proportionally, the average of the written tests (70%), the completion of laboratory practices (20%)
and participation in seminars or other activities proposed in class (10%).
The subject will be passed as long as a final average grade equal to or greater than 5 out of 10 is obtained among the different blocks (Theoretical, Practical and
Stake). It will be possible to add the marks obtained from the Theoretical and Practical block from a mark of 4 out of 10.
THEORETICAL MODULE EVALUATION 70% of the final mark. It will consist of 1 FINAL TEST that may include theoretical concepts, practical cases,
problems etc
PRACTICAL MODULE EVALUATION (20% of the final mark). Attendance at practices is MANDATORY. It will be evaluated by presenting a
laboratory notebook and a knowledge test, although the attitude in the laboratory, compliance with safety regulations and management of
residues may also be considered in the qualification. To pass the practical module, a qualification of AT LEAST 5 POINTS must be obtained and the
The grade may be kept for the following two academic years, if the student so states in writing to the responsible professor.
EVALUATION OF THE ACTIVITIES MODULE (10% of the final mark). Its evaluation will be in the classroom by carrying out the proposed activities
by the teacher. They are NON-MANDATORY. It will only be taken into account once the theoretical-practical block has been passed. The rating can be
retain it for the next two academic years, if the student states so in writing to the responsible professor. If a student could not
carry out any of the evaluable activities of the block of activities in person, for justified reasons, you can ask the teacher for the
carrying out another non-contact activity, of which they will be evaluated, to achieve the competencies.
In the event that the student does not reach the grade required to pass the ordinary call, and has to take the extraordinary one, the qualification of the
Theoretical and practical blocks can only be retained if a minimum score of 4 points has been reached. The activity note is not subject to this rule.
It is recalled that the material prepared by the teacher and made available to students on the Virtual Campus platform is the property of the teacher,
so taking it out of that context and making it available to people outside that platform will be considered plagiarism. Likewise, carrying out
different tests with unauthorized aid or material will be considered fraud. In accordance with the provisions of the Evaluation Regulation of the
student, the test in which fraud has been detected will be considered invalid and will be graded with fail (0), including as a fraudulent act
any type of plagiarism detected.
Specifications for the resit/retake exam:
The final grade will take into account, proportionally, the average of the written tests (70%), the completion of the laboratory practices (20%) and the
participation in seminars or other activities proposed in class (10%).
The subject will be passed as long as a final average grade equal to or greater than 5 out of 10 is obtained among the different blocks (Theoretical, Practical and
Stake). It will be possible to add the marks obtained from the Theoretical and Practical block from a mark of 4 out of 10.
THEORETICAL MODULE EVALUATION 70% of the final mark. It will consist of 1 FINAL TEST that may include theoretical concepts, practical cases,
problems etc
PRACTICAL MODULE EVALUATION (20% of the final mark). For those students who have failed the practical module, they will be able to repeat the exam
of practical knowledge in the EXTRAORDINARY CALL. A grade of AT LEAST 5 POINTS is required to pass the practical module and keep it for the following two academic years.
EVALUATION OF THE ACTIVITIES MODULE (10% of the final mark). THE QUALIFICATION OBTAINED DURING THE CALL IS MAINTAINED
ORDINARY. It will only be taken into account once the theoretical-practical block has been passed. The qualification can be kept during the two academic years
following, if the student manifests it.
It is recalled that the material prepared by the teacher and made available to students on the Virtual Campus platform is the property of the teacher, for
taking it out of that context and making it available to people outside of that platform will be considered plagiarism. Likewise, the realization of the different
Testing with unauthorized aid or material will be considered fraud. In accordance with the provisions of the Student Assessment Regulations, the test in
the one that has been detected fraud will be considered invalid and will be qualified with suspense (0), including any type of plagiarism as a fraudulent act
detected.
participation in seminars or other activities proposed in class (10%).
The subject will be passed as long as a final average grade equal to or greater than 5 out of 10 is obtained among the different blocks (Theoretical, Practical and
Stake). It will be possible to add the marks obtained from the Theoretical and Practical block from a mark of 4 out of 10.
THEORETICAL MODULE EVALUATION 70% of the final mark. It will consist of 1 FINAL TEST that may include theoretical concepts, practical cases,
problems etc
PRACTICAL MODULE EVALUATION (20% of the final mark). For those students who have failed the practical module, they will be able to repeat the exam
of practical knowledge in the EXTRAORDINARY CALL. A grade of AT LEAST 5 POINTS is required to pass the practical module and keep it for the following two academic years.
EVALUATION OF THE ACTIVITIES MODULE (10% of the final mark). THE QUALIFICATION OBTAINED DURING THE CALL IS MAINTAINED
ORDINARY. It will only be taken into account once the theoretical-practical block has been passed. The qualification can be kept during the two academic years
following, if the student manifests it.
It is recalled that the material prepared by the teacher and made available to students on the Virtual Campus platform is the property of the teacher, for
taking it out of that context and making it available to people outside of that platform will be considered plagiarism. Likewise, the realization of the different
Testing with unauthorized aid or material will be considered fraud. In accordance with the provisions of the Student Assessment Regulations, the test in
the one that has been detected fraud will be considered invalid and will be qualified with suspense (0), including any type of plagiarism as a fraudulent act
detected.
Specifications for the second resit / retake exam:
Only those students who meet the requirements stablished by the Student Assessment Regulations of the University of Castilla-La Mancha will be eligible for this call, who will be evaluated according to the criteria applied in the extraordinary call.
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
| Class Attendance (theory) [PRESENCIAL][Combination of methods] | 36 |
| Class Attendance (practical) [PRESENCIAL][Practical or hands-on activities] | 20 |
| Formative Assessment [PRESENCIAL][Assessment tests] | 4 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 90 |
| Global activity | |
|---|---|
| Activities | hours |
| General comments about the planning: | Consult the timetables on the website of the Faculty of Pharmacy and the Virtual Campus. The planning of the will be carried out during the course with the help of the virtual platform of the UCLM. The timetable may be modified in the event of unforeseen circumstances. |
10. Bibliography and Sources
| Author(s) | Title | Book/Journal | Citv | Publishing house | ISBN | Year | Description | Link | Catálogo biblioteca |
|---|---|---|---|---|---|---|---|---|---|
| Portal farmacéutico. Bases de datos del CGCOT (BOT) | https://botplusweb.portalfarma.com/ | ||||||||
| Real Farmacopea Española. 5ª Edición. | Ministerio de Sanidad, Servicios Sociales e Igualdad. Madrid | 2015 | http://biblioteca.uclm.es/ | ||||||
| Agencia Europea del Medicamento | http://emea.europa.eu | ||||||||
| FDA | http://www.fda.gov/ | ||||||||
| Medscape DrugInfo | http://search.medscape.com/reference-search | ||||||||
| The Internet Drug Index | http://www.rxlist.com/script/main/hp.asp | ||||||||
| Allen L.V. | The art, science and technology of pharmaceutical compounding | Ed American Pharmaceutical Association, Washington | 2004 | ||||||
| Alonso M.J., Csaba N. | Nanostructured Biomaterials for Overcoming Biological Barriers | RSC Publishing | 978-1-84973-363-2 | 2012 |
|
||||
| Aulton M.E | La ciencia del diseño de las formas de dosificación. | Elsevier D.L. | 2004 | ||||||
| Faulí y Trillo C. | Tratado de Farmacia Galénica | Luzán 5, S.A. de Ediciones. Madrid | 1993 | ||||||
| Florence, A. T. (Alexander Taylor) | Physicochemical principles of pharmacy | Pharmaceutical Press | 978-0-85369-984-2 | 2011 |
|
||||
| Isabel González Álvarez, Miguel Ángel Cabrera Pérez, Maria del Val Bermejo Sanz | Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos | Universitas Miguel Hernández | 978-84-16024-16-2 | 2015 | |||||
| Martin A. | Physical Pharmacy: Physical chemical principles in the Pharmaceutical Sciences | Lea & Febiger, Philadelphia | 1993 | ||||||
| Martínez Pacheco R. | Tratado de Tecnología Farmacéutica. Volumen I "Sistemas farmacéuticos" | Síntesis | 9788490770986 | 2016 | |||||
| Martínez Pacheco R. | Tratado de Tecnología Farmacéutica. Volumen III "Formas de dosificación" | Síntesis | 9788490771037 | 2017 | |||||
| Martínez Pacheco R. | Tratado de Tecnología Farmacéutica. Volumen II "Operaciones básicas" | Síntesis | 9788490771020 | 2016 | |||||
| Rowe R.C. | Handbook of pharmaceutical excipients | 5ª Edición. Pharmaceutical Press and the American Pharmacists Association | 2005 | ||||||
| Torres Suarez A. | Estabilidad de medicamentos. | Asociación Española de Farmacéuticos de la Industria (AEFI). Madrid | 2004 | ||||||
| Uchegbu I.F., Schatzlein A. | Polymers in drug delivery | CRC/Taylor & Francis | 978-0-8493-2533-5 | 2006 |
|
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| Vila Jato J.L. | Tecnología Farmacéutica II: Formas farmacéuticas | Editorial Síntesis D.L. | 2001 | ||||||
| Vila Jato J.L. | Tecnología Farmacéutica I: Aspectos fundamentales de los sistemas farmacéuticos y operaciones básicas | Editorial Síntesis D.L. | 2001 |