1. General information
Course:
GENERAL PHARMACOLOGY
Code:
14328
Type:
CORE COURSE
ECTS credits:
6
Degree:
376 - UNDERGRADUATE DEGREE PROGRAMME IN PHARMACY
Academic year:
2023-24
Center:
14 - FACULTY OF PHARMACY
Group(s):
10
Year:
3
Duration:
C2
Main language:
Spanish
Second language:
English
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
JOAQUIN JORDAN BUESO
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Medicina
CIENCIAS MÉDICAS
926053222
joaquin.jordan@uclm.es
Lecturer:
BRAULIA MATEOS CARBONERO
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia
CIENCIAS MÉDICAS
Braulia.Mateos@uclm.es
2. Pre-Requisites
Students should consider that in order to pass this course they should have previously taken and passed Human Anatomy, Biology and Organic Chemistry I in the first course; Organic Chemistry II, Physical Chemistry I and II, Biochemistry I and II and Physiology in the second course.
3. Justification in the curriculum, relation to other subjects and to the profession
GENERAL PHARMACOLOGY is one of the subjects that make up Module 5 of the Study Plan of the Degree in Pharmacy of the UCLM to be taught during the second quarter of the 3rd year. Therefore, it is aimed at second cycle students who have already had contact with Basic Sciences in the first cycle. Thus, students should have already passed the recommended previous knowledge to adequately undertake this subject, knowledge that is achieved in other subjects such as Biology, Human Anatomy, Organic Chemistry, Physicochemistry, Physiology, Biochemistry and Molecular Biology. The notions of these other subjects facilitate the learning process and the acquisition of new knowledge about the properties and mechanism of action of drugs to lay the foundations of a rational and effective drug therapy.
From the approaches and objectives of the program detailed below this subject incorporates numerous knowledge and in turn provides essential bases about drugs, on which articulate and support the correct and rational use of them. A thorough knowledge of the physical, chemical and biological interactions on the results of therapy makes pharmacists unique among health professionals in understanding the entity of drugs, the release characteristics of formulations, the distribution of active ingredients in different compartments, and the physiological and pharmacological results of their interactions with the biological organism.
The pharmacist is a drug professional who must possess the ability to find, integrate and apply information from the pharmaceutical sciences to solve pharmacotherapeutic problems, which will allow him/her to:
- Inform and advise on medication to the patient within their pharmaceutical care work.
- Participate and develop teaching tasks aimed at training students of the Degree in Pharmacy and other health professionals.
- Participate in research aimed at the development of new drugs and the identification of possible therapeutic targets.
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| B01 | Proficiency in a second foreign language at level B1 of the Common European Framework of Reference for Languages. |
| B02 | Knowledge of Information and Communication Technologies (ICT). |
| B03 | A correct oral and written communication |
| B04 | Ethical commitment and professional deontology. |
| B05 | Ability to develop those learning skills necessary to undertake further studies. |
| EM01 | Using drugs safely, taking into account their physical properties and the kind of vehicles directly related with their use. |
| EM04 | Study the effects of substances with pharmacological activity. |
| EM05 | Know and understand the techniques used in the design and evaluation of pre-clinical and clinical trials. |
| EM07 | Promote the rational use of medicines and health products. |
| EM08 | Acquire the necessary skills to provide therapeutic advices in pharmacology and dietetics, as well as to give nutritional advice to the users of the establishment where they provide customer service |
| EM12 | Acquire a detailed knowledge about the drugs properties and their mechanism of action |
| EM22 | Interaction of drugs with other drugs or substances. Prevention and treatment. |
| G01 | Identify, design, obtain, analyze, control and produce drugs and medicines, as well as other products and raw materials of sanitary interest for human or veterinary use. |
| G02 | Evaluate the therapeutic and toxic effects of substances with pharmacological activity. |
| G03 | Know how to apply the scientific method and acquire skills in the handling of legislation, sources of information, bibliography, elaboration of protocols and other aspects considered necessary for the design and critical evaluation of preclinical and clinical trials. |
| G04 | Design, prepare, supply and dispense medicines and other products of health interest. |
| G05 | Provide therapeutic advice in pharmacotherapy and dietotherapy, as well as in the nutritional and food field in the establishments where they provide services. |
| G06 | Promote the rational use of medicines and medical devices, as well as to acquire basic knowledge in clinical management, health economics and the efficient use of health resources. |
| G07 | Identify, evaluate and assess problems related to drugs and medicines, as well as participate in pharmacovigilance activities. |
| G08 | Conducting clinical and social pharmacy activities, following the pharmaceutical care cycle. |
| G09 | Intervene in health promotion and disease prevention activities at the individual, family and community levels, with an integral and multi-professional vision of the health-disease process. |
| G10 | Design, apply and evaluate clinical reagents, methods and analytical techniques, knowing the basic principles of clinical analysis and the characteristics and contents of laboratory diagnostic reports. |
| G11 | Evaluate the toxicological effects of substances and design and apply appropriate tests and trials. |
| G12 | Develop hygienic-sanitary analyses, especially those related to food and environment. |
| G13 | Develop communication and information skills, both oral and written, to deal with patients and users of the centre where they carry out their professional activity. Promote the capacity to work and collaborate with multidisciplinary teams and those related to other health professionals. |
| G14 | Know the ethical and deontological principles according to the legislative, regulatory and administrative provisions governing professional practice, understanding the ethical implications of health in a changing social context. |
| G15 | Recognise own limitations and the need to maintain and update professional competence, with particular emphasis on self-learning of new knowledge based on scientific evidence. |
| T01 | Critical thinking skills based on the application of the scientific method |
| T02 | Ability to manage quality scientific information, bibliography, specialized databases and resources accessible through the Internet. |
| T03 | Handling of basic and specific software for the treatment of information and experimental results. |
| T04 | Motivation for quality, safety at work and awareness of environmental issues, with knowledge of the internationally recognised systems for the correct management of these aspects. |
| T05 | Organizational, planning and implementation skills. |
| T06 | Ability to address human resources decision-making and management. |
| T07 | Ability to work as a team and, where appropriate, exercise leadership functions, encouraging entrepreneurship. |
| T08 | Develop interpersonal skills and the ability to function in an international and multicultural context. |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| Acquire a detailed knowledge for the use of drugs database useful to the search for information on drugs and related topics. | |
| Learning basic pharmacological terminology, and acquire a detailed knowledge about pharmacological targets and pharmacokinetics processes suffered by drugs in the body. | |
| Identify and evaluate the different types of adverse reactions associated with the pharmacological treatments. | |
| Solving and interpretation of experimental data. Learning the right handling of the experimental animal. | |
| Identify the most common types of pharmacological interactions. Learning to visualize and detect new potential interactions. | |
| Identifying the different effects derived from the pharmacological action, differentiating the main effects and the side effects, leading the projection towards the understanding and rationalization of therapeutics. | |
| Promote the rational use of drugs. | |
| Additional outcomes | |
| Not established. |
6. Units / Contents
-
Unit 1: Introduction and historical evolution of Pharmacology
-
Unit 2: Generalities. Pharmacokinetics and Pharmacodynamics.
-
Unit 3: Absorption and transport of drugs.
-
Unit 4: Distribution of drugs in the organism.
-
Unit 5: Elimination of drugs from the body
-
Unit 6: Drug-drug interaction.
-
Unit 7: Types of drug targets
-
Unit 8: Routes of drug administration
-
Unit 9: Drug-drug interactions. Drug-drug, drug-nutrient
-
Unit 10: Special situations that modify the response to drugs.
-
Unit 11: Adverse drug reactions
-
Unit 12: Laboratory practicals
-
Unit 12.1: Study of drug-receptor interaction
-
Unit 12.2: Effects of drugs on the cell cycle
-
Unit 12.3: Introduction to animal experimentation.
-
-
Unit 13: Pharmacogenetics
ADDITIONAL COMMENTS, REMARKS
The specific content of the topics will be made available on Moodle.
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Combination of methods | B01 B02 B03 B04 B05 EM01 EM04 EM05 EM07 EM08 EM12 EM22 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 1.44 | 36 | Y | N | The availability of teaching resources will be accessible on the moodel platform before the beginning of the activities. Students will have access to complementary bibliographic material in the university library of the Albacete campus. Along with the presentation of the topics of the subject through lectures, the active participation of the student will be valued through cooperative work both in the classroom and outside it, the preparation and defense of seminars that will be presented orally, as well as the resolution of problems and / or cases and case studies. All this will be taken into account in the final evaluation of the participation in the course. | |
| Class Attendance (practical) [ON-SITE] | Practical or hands-on activities | B01 B02 B03 B04 B05 EM01 EM04 EM05 EM07 EM08 EM12 EM22 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.8 | 20 | Y | Y | They will be taught in small groups within the periods established in the academic calendar and will not coincide with other activities. They will be carried out in laboratories equipped with all the appropriate means to achieve the proposed objectives. These activities are MANDATORY, so that the student will not be able to pass the course if they are not carried out properly. | |
| Study and Exam Preparation [OFF-SITE] | Self-study | B01 B02 B03 B04 B05 EM01 EM04 EM05 EM07 EM08 EM12 EM22 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 3.6 | 90 | Y | N | The student may request personal tutoring on the contents of the course by arranging an interview via e-mail. | |
| Formative Assessment [ON-SITE] | Assessment tests | B01 B02 B03 B04 B05 EM01 EM04 EM05 EM07 EM08 EM12 EM22 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.16 | 4 | Y | N | Dates have been reserved in the academic calendar so that the evaluation tests do not coincide with the academic calendar. | |
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Theoretical exam | 70.00% | 70.00% | It will consist of 2 partial tests (continuous evaluation) that may include theoretical concepts, topics covered in the practicals or in the different teaching activities, problems or clinical cases, etc. The student who passes the 4 in the first final exam may decide whether to take the whole course, or to eliminate the contents corresponding to the first final exam for the second one. This decision will have to be notified to the professor responsible for the subject via e-mail at least 2 weeks before the date of the second final exam. |
| Laboratory sessions | 20.00% | 20.00% | Attendance to practical sessions is MANDATORY in order to pass the course, the practical sessions will NOT be recoverable. The evaluation will be done by means of a written exam and the presentation of a laboratory notebook. The grade obtained will represent a maximum of 20% of the final grade of the course. If the student does not pass the practical block in the ordinary call, he/she will have another opportunity to do it in the extraordinary call. Once the practical block has been passed, the grade obtained in this block will be kept for the following two academic years, only if the grade is 5 points out of 10. |
| Assessment of active participation | 10.00% | 10.00% | The completion of assignments, presentation of seminars or any other activity proposed by the professor may account for up to 10% of the grade for the course. This valuation will only be considered in the final grade as long as the theoretical and practical blocks have been passed. |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:It will be assumed that all students opt for the continuous mode, unless otherwise informed (non-continuous mode) by e-mail to the professor responsible for the subject. Any student may change to the non-continuous evaluation mode if he/she has not completed at least 50% of all evaluable activities or if the class period has ended.
The ordinary call will consist of an evaluation of the theoretical knowledge acquired (Theoretical Block), an evaluation of the completion of the practices (Practical Block) and the evaluation of the student's participation and achievement.
EVALUATION OF THE THEORETICAL BLOCK: It will consist of 2 partial tests (continuous evaluation) that may include theoretical concepts, topics covered in the practicals or in the different teaching activities, clinical problems or cases, etc. The student who passes the 4 in the first final exam may decide whether to take the whole course, or to eliminate the contents corresponding to the first final exam for the second one. This decision will have to be notified to the teacher responsible for the subject via e-mail at least 2 weeks before the date of the second final exam.
70% of the final grade of the course, corresponding to the theoretical block, will be distributed equally in these two partial tests.
EVALUATION PRACTICAL BLOCK: Attendance to practical sessions is COMPULSORY in order to pass the course, the practical sessions will NOT be recoverable. The evaluation will be done by means of a written exam and the presentation of a laboratory notebook. The grade obtained will represent a maximum of 20% of the final grade of the course. If the student does not pass the practical block in the ordinary exam, he/she will have another opportunity to do it in the extraordinary exam. Once the practical block has been passed, the grade obtained in this block will be kept for the following two academic years, only if the grade is 5 points out of 10.
EVALUATION OF ACTIVITIES (10%): Evaluation of problem solving, elaboration of works and active participation.The activities of this block are NOT COMPULSORY.The date on which these activities will be carried out will be exposed in the virtual campus during the first three weeks of each term.The evaluation of these activities will represent a maximum of 10% of the final grade of the course.
The course will be considered passed when the final grade is equal or higher than 5 points out of 10. The minimum grade in the theoretical and practical blocks must be equal or higher than 4 points out of 10 in each block. The grade corresponding to the activities (maximum 10% of the final grade) will only be added to the global computation in the case that the student has reached 4 out of 10 in the theoretical and practical blocks.
It is reminded that the material prepared by the teacher and made available to students on the Virtual Campus platform is the property of the teacher, so taking it out of that context and making it available to people outside that platform will be considered plagiarism.
Likewise, the completion of the different tests with unauthorized help or material will be considered fraud.In accordance with the provisions of Article 8 of the Student Evaluation Regulations, the test in which fraud has been detected will be considered invalid and will be graded with a fail (0), including as a fraudulent act any type of plagiarism detected. -
Non-continuous evaluation:Any student may change to the non-continuous evaluation modality after notifying the professor in charge, provided that he/she has not completed at least 50% of all the evaluable activities or the class period has ended. The ordinary call will consist of an evaluation of the theoretical knowledge acquired (Theoretical Block), an evaluation of the completion of the practices (Practical Block) and the evaluation of the student's participation and achievement.
EVALUATION OF THE THEORETICAL BLOCK (70%): It will consist of a compulsory and recoverable final test that may include theoretical concepts, topics covered in the practicals or in the different teaching activities, problems or clinical cases, etc. The theoretical part of the final grade of the course will be the one obtained in this test. The student who does not pass this final test will have the possibility of passing the course in the extraordinary exam, which, like the previous exam, will have a value of 70% of the final grade of the course.
PRACTICAL EVALUATION: Attendance to practical sessions is MANDATORY in order to pass the course and the practical sessions will NOT be recoverable. The evaluation will be done by means of a written exam and the presentation of a laboratory notebook. The grade obtained will represent a maximum of 20% of the final grade of the course. If the student does not pass the practical block in the ordinary exam, he/she will have another opportunity to do it in the extraordinary exam. Once the practical block has been passed, the grade obtained in this block will be kept for the following two academic years, only if the grade is 5 points out of 10.
ASSESSMENT OF ACTIVITIES (10% of the final grade):Evaluation of problem solving, work elaboration and active participation.The activities of this block are NOT COMPULSORY.The date on which these activities will be carried out will be posted on the virtual campus during the first three weeks of each term.Students who cannot perform the evaluable activities in the block of participation in person may request the teacher to perform an alternative activity which will be evaluated. The evaluation of these activities will represent a maximum of 10% of the final grade of the course.
The course will be considered passed when the final grade is equal to or higher than 5 points out of 10. The minimum grade in the theoretical and practical blocks must be equal to or higher than 4 points out of 10 in each block. The grade corresponding to the activities (maximum 10% of the final grade) will only be added to the global computation in the case that the student has reached 4 out of 10 in the theoretical and practical blocks.
Specifications for the resit/retake exam:
The extraordinary call, for students who have not passed the course in the ordinary call, will consist of a final compulsory non-recoverable test that will account for 90% of the final grade of the course. It will consist of a theoretical part that will account for 70% of the grade, and a practical part that will account for 20% of the final grade. The recovery of the practical part can only be done in the case that the student has attended all the practices, and has not passed the evaluation in ordinary call.
The student will have to pass independently each of the two parts (theory and practice).
In case of having passed the theoretical or practical block in the ordinary exam with more than a 4, it will not be necessary to take that part of the final exam to pass the subject in the extraordinary exam if the student so requests. Once the student has passed the extraordinary final exam, the percentage corresponding to the grade obtained in the evaluation of the student's participation and achievement will be added, but only in the case that the student has reached 4 out of 10 in the theoretical and practical blocks.
The student will have to pass independently each of the two parts (theory and practice).
In case of having passed the theoretical or practical block in the ordinary exam with more than a 4, it will not be necessary to take that part of the final exam to pass the subject in the extraordinary exam if the student so requests. Once the student has passed the extraordinary final exam, the percentage corresponding to the grade obtained in the evaluation of the student's participation and achievement will be added, but only in the case that the student has reached 4 out of 10 in the theoretical and practical blocks.
Specifications for the second resit / retake exam:
Only students who meet the requirements set forth in the Student Evaluation Regulations of the University of Castilla-La Mancha will be eligible for this call and will be evaluated according to the criteria applied in the extraordinary call.
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
| Class Attendance (theory) [PRESENCIAL][Combination of methods] | 36 |
| Class Attendance (practical) [PRESENCIAL][Practical or hands-on activities] | 20 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 90 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 4 |
| Global activity | |
|---|---|
| Activities | hours |