1. General information
Course:
ORGANIC CHEMISTRY II
Code:
14318
Type:
CORE COURSE
ECTS credits:
6
Degree:
376 - UNDERGRADUATE DEGREE PROGRAMME IN PHARMACY
Academic year:
2023-24
Center:
14 - FACULTY OF PHARMACY
Group(s):
10
Year:
2
Duration:
First semester
Main language:
Spanish
Second language:
English
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
JOAQUIN CALIXTO GARCIA MARTINEZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia
QUÍMICA INORG., ORG., Y BIOQ.
+34926053224
joaquinc.garcia@uclm.es
Lecturer:
ANTONIO MANUEL RODRÍGUEZ GARCÍA
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia
QUÍMICA INORG., ORG., Y BIOQ.
AntonioM.Rodriguez@uclm.es
2. Pre-Requisites
There are no prerequisites for this course; however, it is recommended that students have previously taken General Chemistry and Introduction to Laboratory. As it is the second subject in the Organic Chemistry module, it is also recommended to have completed Organic Chemistry I.
3. Justification in the curriculum, relation to other subjects and to the profession
As experts in medications and their therapeutic use in humans, future pharmacists must have knowledge of the chemical structure and properties of the main groups of natural products and heterocycles, as many drugs mimic the structure and functions of many of them. This subject, along with Organic Chemistry I, forms the foundation for Pharmaceutical Chemistry I and Pharmaceutical Chemistry II. Additionally, this course introduces the concepts of characterization and structural determination using spectroscopic techniques, primarily nuclear magnetic resonance (NMR) and infrared spectroscopy (IR).
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| B01 | Proficiency in a second foreign language at level B1 of the Common European Framework of Reference for Languages. |
| B02 | Knowledge of Information and Communication Technologies (ICT). |
| B03 | A correct oral and written communication |
| B04 | Ethical commitment and professional deontology. |
| B05 | Ability to develop those learning skills necessary to undertake further studies. |
| EQ01 | Identify, design, prepare, analyse and produce active principles, drugs and other materials and products of sanitary interest. |
| EQ02 | Adequately choose the techniques and methodologies for the evaluation, design and application of chemical reagents, laboratory methodologies and analytical techniques. |
| EQ03 | Complete standard laboratory processes including the employment of scientific equipment related to synthesis and analysis. |
| EQ04 | Evaluate risks/hazards associated to the use of chemical substances and lab processes. |
| EQ08 | Know and understand the chemical nature and behavior of functional groups in organic molecules. |
| EQ11 | Know and apply the main structural determination techniques, including spectroscopy. |
| G01 | Identify, design, obtain, analyze, control and produce drugs and medicines, as well as other products and raw materials of sanitary interest for human or veterinary use. |
| G02 | Evaluate the therapeutic and toxic effects of substances with pharmacological activity. |
| G03 | Know how to apply the scientific method and acquire skills in the handling of legislation, sources of information, bibliography, elaboration of protocols and other aspects considered necessary for the design and critical evaluation of preclinical and clinical trials. |
| G04 | Design, prepare, supply and dispense medicines and other products of health interest. |
| G05 | Provide therapeutic advice in pharmacotherapy and dietotherapy, as well as in the nutritional and food field in the establishments where they provide services. |
| G06 | Promote the rational use of medicines and medical devices, as well as to acquire basic knowledge in clinical management, health economics and the efficient use of health resources. |
| G07 | Identify, evaluate and assess problems related to drugs and medicines, as well as participate in pharmacovigilance activities. |
| G08 | Conducting clinical and social pharmacy activities, following the pharmaceutical care cycle. |
| G09 | Intervene in health promotion and disease prevention activities at the individual, family and community levels, with an integral and multi-professional vision of the health-disease process. |
| G10 | Design, apply and evaluate clinical reagents, methods and analytical techniques, knowing the basic principles of clinical analysis and the characteristics and contents of laboratory diagnostic reports. |
| G11 | Evaluate the toxicological effects of substances and design and apply appropriate tests and trials. |
| G12 | Develop hygienic-sanitary analyses, especially those related to food and environment. |
| G13 | Develop communication and information skills, both oral and written, to deal with patients and users of the centre where they carry out their professional activity. Promote the capacity to work and collaborate with multidisciplinary teams and those related to other health professionals. |
| G14 | Know the ethical and deontological principles according to the legislative, regulatory and administrative provisions governing professional practice, understanding the ethical implications of health in a changing social context. |
| G15 | Recognise own limitations and the need to maintain and update professional competence, with particular emphasis on self-learning of new knowledge based on scientific evidence. |
| T01 | Critical thinking skills based on the application of the scientific method |
| T02 | Ability to manage quality scientific information, bibliography, specialized databases and resources accessible through the Internet. |
| T03 | Handling of basic and specific software for the treatment of information and experimental results. |
| T04 | Motivation for quality, safety at work and awareness of environmental issues, with knowledge of the internationally recognised systems for the correct management of these aspects. |
| T05 | Organizational, planning and implementation skills. |
| T06 | Ability to address human resources decision-making and management. |
| T07 | Ability to work as a team and, where appropriate, exercise leadership functions, encouraging entrepreneurship. |
| T08 | Develop interpersonal skills and the ability to function in an international and multicultural context. |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| Preparation of reports, summaries and presentations on bibliographic or experimental works, either individually or in teams, applying the capacity for criticism and self-criticism. | |
| Ability to design simple organic compound synthesis from certain starting products and involving more than one reaction. | |
| Ability to name organic compounds according to IUPAC standards and represent their structure from the systematic name. | |
| Correlate the structure of organic compounds with their physical properties, reactivity and stability. | |
| Characterization and identification of functional groups in organic compounds. | |
| Ability to apply the knowledge acquired in laboratory practice and in solving problems and issues related to organic compounds. | |
| To develop the necessary laboratory processes for the transformation, separation, isolation and purification of organic compounds, estimating the possible associated risks. | |
| Structural determination of organic compounds from their chemical properties and chemical analysis data. | |
| Recognize the three-dimensional structure of organic compounds and its implications. | |
| Additional outcomes | |
| Not established. |
6. Units / Contents
-
Unit 1: Structural Determination of Organic Compounds
-
Unit 1.1: Infrared Absorption Spectroscopy
-
Unit 1.2: Nuclear Magnetic Resonance Spectroscopy (NMR)
-
-
Unit 2: Electrophilic Aromatic Substitution (SEAr)
-
Unit 2.1: Electrophilic Aromatic Substitution Reactions on Benzene
-
Unit 2.2: Mechanism of Electrophilic Aromatic Substitution Reaction
-
Unit 2.3: Strategies for the Synthesis of Substituted Benzenes
-
Unit 2.4: Polynuclear Hydrocarbons
-
-
Unit 3: Heterocyclic Organic Compounds
-
Unit 3.1: Aromaticity and Heteroaromaticity
-
Unit 3.2: Six-Membered Aromatic Heterocycles
-
Unit 3.3: Five-Membered Aromatic Heterocycles
-
Unit 3.4: Synthesis of Aromatic Heterocycles
-
-
Unit 4: Amino Acids, Peptides, and Proteins
-
Unit 4.1: Structure of Amino Acids and Peptides. Stereochemistry and Nomenclature of Amino Acids
-
Unit 4.2: Acid-Base Properties
-
Unit 4.3: Synthesis of Amino Acids
-
Unit 4.4: Reactivity of Amino Acids
-
Unit 4.5: Peptides
-
Unit 4.6: Peptide Synthesis
-
-
Unit 5: Carbohydrates and Nucleic Acids
-
Unit 5.1: Classification of Carbohydrates
-
Unit 5.2: Cyclic Forms of Carbohydrates
-
Unit 5.3: Mutarotation
-
Unit 5.4: Other Sugars. Glycosides. Disaccharides. Polysaccharides
-
Unit 5.5: Reactivity of Monosaccharides
-
Unit 5.6: Nucleic Acids
-
-
Unit 6: Laboratory Practices
-
Unit 6.1: Synthesis con Cinnamic Acid. Use of Spectroscopic techniques
-
Unit 6.2: ArES. Synthesis of Martius Yellow
-
Unit 6.3: Synthesis of Knorr.
-
Unit 6.4: Chemistry of Milk. Proteins and Carbohydrates
-
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Lectures | B01 B02 B03 B04 B05 EQ01 EQ02 EQ08 EQ11 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.92 | 23 | Y | N | The availability of teaching resources will be accessible on the Moodle platform prior to the start of activities. Additionally, students will have access to supplementary bibliographic and audiovisual material (books, review articles, videos) both in the university library on the Albacete campus and on the Virtual Campus. | |
| Laboratory practice or sessions [ON-SITE] | Practical or hands-on activities | B01 B02 B03 B04 B05 EQ02 EQ03 EQ04 EQ08 EQ11 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.8 | 20 | Y | Y | Practical teaching will be delivered in small groups within designated periods on the academic calendar that do not coincide with other teaching activities. These sessions will take place in classrooms and/or laboratories, all equipped with the necessary resources to achieve the intended objectives. These activities are MANDATORY, meaning that students will not be able to pass the course if they do not complete them adequately. The knowledge acquired during these practical sessions will be assessed through the completion and grading of a laboratory notebook, the completion and grading of teaching activities related to Applied Organic Chemistry, and through observation of attitude and daily performance in the laboratory. | |
| Workshops or seminars [ON-SITE] | Combination of methods | B01 B02 B03 B04 B05 EQ01 EQ02 EQ08 EQ11 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.52 | 13 | Y | N | Participation will be assessed through the completion of questionnaires, online quizzes, and the submission of problem-solving seminars. The teaching methodologies employed will include workshops and seminars, study and problem/case resolution, and assessment tests. In the case of case studies, they provide a practical and specific perspective on problems or phenomena in Organic Chemistry, facilitating critical analysis and the application of theoretical concepts to real-life situations. | |
| Study and Exam Preparation [OFF-SITE] | Self-study | B01 B02 B03 B04 B05 EQ01 EQ02 EQ03 EQ04 EQ08 EQ11 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 3.6 | 90 | Y | N | Students will have the opportunity to request personal tutoring on course content by scheduling an appointment with the respective professor. | |
| Formative Assessment [ON-SITE] | Assessment tests | B01 B02 B03 B04 B05 EQ01 EQ02 EQ03 EQ04 EQ08 EQ11 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.16 | 4 | Y | N | Specific dates for evaluation tests have been reserved in the academic calendar, which do not coincide with other teaching activities. These tests will be evaluated based on the scoring of the problems and questions presented in them. | |
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Test | 70.00% | 70.00% | Refer to the assessment section |
| Laboratory sessions | 20.00% | 20.00% | The practical sessions are, in ALL CASES, mandatory non-recoverable activities. |
| Assessment of active participation | 10.00% | 10.00% | Refer to the assessment section |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:It will be assumed that all students choose the continuous assessment mode unless otherwise informed (non-continuous mode) by sending an email to the responsible professor of the subject, provided it is done before the student has completed 50% of all assessable activities or the class period has ended.
The subject will be passed when a minimum score of 5 points is obtained in the overall grade. To add up the grades of the two main components (theory and practice), it will be necessary to have obtained a minimum of 4 points in each of them, regardless of the mode of assessment.
THEORETICAL COMPONENT EVALUATION (70% of the final grade). It will consist of 2 non-mandatory partial exams (continuous assessment) and/or 1 mandatory and recoverable final exam (if continuous assessment is not passed). The partial exams will have a weight of 50% for the first exam and 50% for the second exam in the theoretical component.
PRACTICAL COMPONENT EVALUATION (20% of the final grade). Attendance to laboratory practical sessions is MANDATORY to pass the subject in the regular assessment period, and the practical sessions will NOT be recoverable. It will be evaluated through the submission of a laboratory notebook, attitude and performance in the laboratory, compliance with safety regulations, and waste management. To pass the practical module in the regular assessment period, students must attend all practical sessions and obtain a grade of at least 4 out of 10 in the arithmetic mean between the grade of the notebook and the practical sessions themselves. This grade will be maintained for the following two academic years.
Students who have failed the practical module in the regular assessment period but have attended all practical sessions will take a written exam on practical knowledge in the extraordinary assessment period.
PARTICIPATION EVALUATION (10% of the final grade). It will be evaluated through the submission of problem-solving seminars in the virtual campus and in the classroom (by completing activities proposed by the professor). These activities are NON-MANDATORY and RECOVERABLE.
It is reminded that the materials created by the professor and made available to students on the Virtual Campus platform are the property of the professor. Therefore, taking them out of that context and making them available to individuals not enrolled in the platform without the professor's consent will be considered a violation of copyright. Likewise, it is prohibited to record classes and other activities without the explicit consent of the professor. The use of unauthorized aids or materials during exams will be considered fraud. In accordance with Article 8 of the Student Assessment Regulations, any exam in which fraud is detected will be considered invalid and graded as a fail (0), including plagiarism. -
Non-continuous evaluation:To choose this form of assessment, it is necessary to request it by sending an email to the responsible professor of the subject, provided it is done before the student has completed 50% of all assessable activities or the class period has ended.
The subject will be passed when a minimum score of 5 points is obtained in the overall grade. To add up the grades of the two main components (theory and practice), it will be necessary to have obtained a minimum of 4 points in each of them, regardless of the mode of assessment.
THEORETICAL COMPONENT EVALUATION (70% of the final grade). It will consist of ONE mandatory and recoverable final exam.
PRACTICAL COMPONENT EVALUATION (20% of the final grade). Attendance to laboratory practical sessions is MANDATORY to pass the subject in the regular assessment period, and the practical sessions will NOT be recoverable. It will be evaluated through the submission of a laboratory notebook, attitude and performance in the laboratory, compliance with safety regulations, and waste management. To pass the practical module in the regular assessment period, students must attend all practical sessions and obtain a grade of at least 4 out of 10 in the arithmetic mean between the grade of the notebook and the practical sessions themselves. This grade will be maintained for the following two academic years.
Students who have failed the practical module in the regular assessment period but have attended all practical sessions will take a written exam on practical knowledge in the extraordinary assessment period.
PARTICIPATION EVALUATION (10% of the final grade). To pass, specific activities will be proposed to the student. These activities are NON-MANDATORY and RECOVERABLE (see the section on Extraordinary Assessment Specifics).
It is reminded that the materials created by the professor and made available to students on the Virtual Campus platform are the property of the professor. Therefore, taking them out of that context and making them available to individuals not enrolled in the platform without the professor's consent will be considered a violation of copyright. Likewise, it is prohibited to record classes and other activities without the explicit consent of the professor. The use of unauthorized aids or materials during exams will be considered fraud. In accordance with Article 8 of the Student Assessment Regulations, any exam in which fraud is detected will be considered invalid and graded as a fail (0), including plagiarism.
Specifications for the resit/retake exam:
The subject will be passed when a minimum score of 5 points is obtained in the overall grade. In order to combine the grades of the two main components (theory and practice), it will be necessary to have obtained at least a 4 in each of them independently.
THEORETICAL COMPONENT EVALUATION (70% of the final grade). It will consist of a mandatory and non-recoverable final exam.
PRACTICAL MODULE EVALUATION (20% of the final grade). Students who have failed the practical module in the regular assessment period but have attended all practical sessions will take a written exam on practical knowledge in the extraordinary assessment period.
PARTICIPATION EVALUATION (10% of the final grade). The grade obtained during the regular assessment period will be maintained. However, in the case of students who did not participate in this module during the regular assessment period, they may recover it by completing an original work that will be orally presented to the professor, upon prior request via email to the responsible professor of the subject (before 15 natural days prior to the date of the extraordinary exam). The grade can be maintained for the following two academic years if the student expresses their intention to do so.
THEORETICAL COMPONENT EVALUATION (70% of the final grade). It will consist of a mandatory and non-recoverable final exam.
PRACTICAL MODULE EVALUATION (20% of the final grade). Students who have failed the practical module in the regular assessment period but have attended all practical sessions will take a written exam on practical knowledge in the extraordinary assessment period.
PARTICIPATION EVALUATION (10% of the final grade). The grade obtained during the regular assessment period will be maintained. However, in the case of students who did not participate in this module during the regular assessment period, they may recover it by completing an original work that will be orally presented to the professor, upon prior request via email to the responsible professor of the subject (before 15 natural days prior to the date of the extraordinary exam). The grade can be maintained for the following two academic years if the student expresses their intention to do so.
Specifications for the second resit / retake exam:
Only students who meet the requirements stated in the Student Assessment Regulations of the University of Castilla-La Mancha will be eligible to participate in this extraordinary assessment. They will be evaluated according to the criteria applied in the extraordinary assessment period.
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 23 |
| Laboratory practice or sessions [PRESENCIAL][Practical or hands-on activities] | 20 |
| Workshops or seminars [PRESENCIAL][Combination of methods] | 13 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 51.75 |
| Formative Assessment [PRESENCIAL][Assessment tests] | 4 |
| Global activity | |
|---|---|
| Activities | hours |
10. Bibliography and Sources
| Author(s) | Title | Book/Journal | Citv | Publishing house | ISBN | Year | Description | Link | Catálogo biblioteca |
|---|---|---|---|---|---|---|---|---|---|
| La editorial Digitalia tiene varios libros de Química Orgánica | Acceso on line libre para alumnos | http://www.digitaliapublishing.com/ | |||||||
| La editorial Pearson tiene varios libros de Química Orgánica | Acceso on line libre para alumnos | http://www.conten.es/ib/NPortada?CodPortada=1000188 | |||||||
| Cabildo, M.P; García, A; López, C. Santa, M.D. Gutiérrez, M. | Química orgánica / | UNED | 978-84-362-5528-7 | 2022 | https://www.librosuned.com/LU616/Quimica-org%E1nica-.aspx |
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| Carey, Francis A. | Química orgánica / | McGraw Hill, | 978-607-15-1210-9 | 2014 |
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| Chaloner, P. | Organic chemistry: a mechanistic approach | CRC Press. | 978-0-19-969327-6 | 2014 | https://www.taylorfrancis.com/books/mono/10.1201/b17689/organic-chemistry-penny-chaloner |
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| D'Auria, M. V. | Guía razonada para resolver problemas de química orgánica : | Loghia, | 978-88-95122-45-8 | 2018 | https://loghia.com/shop/index.php?id_product=54&controller=product&id_lang=4 |
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| Ege, S. | Química orgánica : estructura y reactividad / | Reverté, | 978-84-291-7067-2 (O | 2013 |
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| García Calvo-Flores, F. | Problemas resueltos de química orgánica / | Thomson, | 978-84-9732-458-8 | 2015 |
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| González Rosende, M. E. | Fundamentos de química orgánica para ciencias de la salud / | Ed. Síntesis | 978-84-9171-092-9 ( | 2017 | https://www.sintesis.com/manuales%20de%20químicas-198/fundamentos%20de%20química%20orgánica%20para%20ciencias%20de%20la%20salud.%20volumen%201-ebook-2442.html |
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| Gómez Aspe, R. | Teoría y problemas resueltos de química orgánica / | Ed. Síntesis | 978-84-9958-884-1 | 2013 | https://www.sintesis.com/biblioteca%20de%20química-138/teoría%20y%20problemas%20resueltos%20de%20química%20orgánica-ebook-1793.html |
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| Hesse, M., Meier, H., Zeeh, B. | Métodos Espectroscópicos en Química Orgánica | Ed. Síntesis | 9788477385226 | 2005 | https://www.sintesis.com/química%20básica-140/métodos%20espectroscópicos%20en%20química%20orgánica-libro-1106.html | ||||
| Klein, D. R. | Química orgánica / | Médica Panamericana, | 978-84-9835-169-9 | 2013 |
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| Soler Martínez, V.; González Rosend, M.E. | Química Orgánica para Ciencias de la Salud | Ed. Sintesis | 9788497569347 | 2008 | https://www.sintesis.com/biblioteca-de-quimica-138/quimica-organica-para-ciencias-de-la-salud-ebook-1299.html | ||||
| Soto Cámara, J. L. | Química orgánica. Vol. 3: Grupos funcionales y heterociclos | Ed. Síntesis | 84-7738-906-3 (o. c. | 2005 | https://www.sintesis.com/química%20básica-140/química%20orgánica.%20vol.%20iii.%20grupos%20funcionales%20y%20heterociclos-ebook-1301.html |
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| Soto Cámara, J. L. | Química orgánica. Vol. 2: hidrocarburos y sus derivados halógenos | Ed. Síntesis | 8477389055 | 2001 | https://www.sintesis.com/química%20básica-140/química%20orgánica.%20volumen%20ii%3A%20hidrocarburos%20y%20sus%20derivados%20halogenados-ebook-1302.html |
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| Soto Cámara, J. L. | Química Orgánica. Vol. 1: Conceptos básicos | Ed. Sintesis | 9788499581453 | 2010 | https://www.sintesis.com/química%20básica-140/química%20orgánica.%20vol.%20i%3A%20conceptos%20básicos-ebook-1300.html | ||||
| Vollhardt, K.; Peter C. | Química orgánica : estructura y función | Omega | 978-84-282-1431-5 | 2007 |
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| Vollhardt, K.; Peter C. | Organic chemistry : structure and function | W.H. Freeman, | 1-319-18771-4 | 2018 |
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| Wade, Leroy G. | Química orgánica / vol.2 | Pearson, | 9786073238496 | 2017 | https://pearson.es/españa/TiendaOnline/química-orgánica-9e-vol-ii | ||||
| Wade, Leroy G. | Química orgánica / vol.1 | Pearson, | 978-607-32-3847-2 ( | 2017 | https://pearson.es/españa/TiendaOnline/química-orgánica-9e-vol-i |
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