1. General information
Course:
MOLECULAR PATHOLOGY
Code:
13322
Type:
CORE COURSE
ECTS credits:
6
Degree:
341 - UNDERGRADUATE DEGREE PROGRAMME IN BIOCHEMISTRY
Academic year:
2023-24
Center:
501 - FACULTY OF ENVIRONMENTAL SCIENCES AND BIOCHEMISTRY
Group(s):
40
Year:
3
Duration:
First semester
Main language:
Spanish
Second language:
English
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
ARACELI DEL ARCO MARTINEZ
- Group(s):
40
Building/Office
Department
Phone number
Email
Office hours
Sabatini, despacho 0.26
QUÍMICA INORG., ORG., Y BIOQ.
5477
araceli.arco@uclm.es
Lecturer:
YOLANDA CAMPOS MARTIN
- Group(s):
40
Building/Office
Department
Phone number
Email
Office hours
Edificio 6/10
QUÍMICA INORG., ORG., Y BIOQ.
Yolanda.Campos@uclm.es
2. Pre-Requisites
Not established
3. Justification in the curriculum, relation to other subjects and to the profession
Not established
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| E01 | Express themselves correctly in basic biological, physical, chemical, mathematical and computer terms. |
| E11 | To have an integrated vision of the cellular functioning of both the metabolism and the gene expression, being able to relate the activity of the different cellular compartments. |
| E19 | Understand the principles that determine the three-dimensional structure of biological molecules, macromolecules and supramolecular complexes and be able to explain the relationships between structure and function. |
| E20 | To know the biochemical and molecular bases of the control of gene expression and the activity, location and replacement of cellular proteins. |
| E22 | Have an integrated view of the intercellular communication and intracellular signalling systems that regulate the proliferation, differentiation, development and function of animal and plant tissues and organs. |
| E23 | To know the components, functioning and regulation mechanisms of plant and animal organisms, with special emphasis on the human species. |
| E30 | To know the biochemical and genetic changes of a wide range of pathologies and to know how to explain the molecular mechanisms involved in these changes. |
| G06 | Acquire skills in the handling of computer programs including access to bibliographic, structural or any other type of databases useful in Biochemistry and Molecular Biology. |
| T01 | Proficiency in a second foreign language, preferably English, at level B1 of the Common European Framework of Reference for Languages |
| T02 | User-level knowledge of Information and Communication Technologies (ICT). |
| T03 | A correct oral and written communication |
| T05 | Organizational and planning skills |
| T06 | Capacity for design, analysis and synthesis |
| T07 | Ability to address decision making. |
| T08 | Ability to work as a team and, where appropriate, exercise leadership functions, encouraging entrepreneurship |
| T10 | Ability to self-learn and to obtain and manage bibliographic information, including Internet resources |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| Understand the main methods of studying human diseases. | |
| Know how to explain the molecular bases of genetic diseases in their different mechanisms. | |
| To know the structural and functional characteristics of the immune system. | |
| Understand the molecular and genetic mechanisms underlying major pathologies. | |
| To know the metabolic and functional repercussions of the main pathologies. | |
| To know the basic strategies and tools used in genetic analysis. | |
| Additional outcomes | |
| Description | |
6. Units / Contents
-
Unit 1:
-
Unit 2:
-
Unit 3:
-
Unit 4:
-
Unit 5:
-
Unit 6:
-
Unit 7:
-
Unit 8:
-
Unit 9:
-
Unit 10:
-
Unit 11:
-
Unit 12:
-
Unit 13:
-
Unit 14:
-
Unit 15:
-
Unit 16:
-
Unit 17:
-
Unit 18:
-
Unit 19:
-
Unit 19.1:
-
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Lectures | E11 E19 E20 E22 E23 E30 T01 | 1.7 | 42.5 | N | N | ||
| Laboratory practice or sessions [ON-SITE] | Combination of methods | E01 E11 E19 E20 E22 E23 E30 T01 | 0.4 | 10 | Y | Y | ||
| Practicum and practical activities report writing or preparation [OFF-SITE] | Self-study | E01 E30 T01 | 0.16 | 4 | Y | N | ||
| Other on-site activities [ON-SITE] | Problem solving and exercises | E01 E19 E20 E22 E30 G06 T03 T05 | 0.16 | 4 | Y | N | ||
| Group tutoring sessions [ON-SITE] | Guided or supervised work | T10 | 0.02 | 0.5 | Y | N | ||
| Other on-site activities [ON-SITE] | Group Work | E01 | 0.04 | 1 | Y | N | ||
| Final test [ON-SITE] | Assessment tests | E01 E11 E19 E20 E22 E23 E30 T03 T05 T06 | 0.08 | 2 | Y | Y | ||
| Study and Exam Preparation [OFF-SITE] | Self-study | 2.48 | 62 | N | N | |||
| Writing of reports or projects [OFF-SITE] | Group Work | E01 E11 E19 E20 E22 E23 E30 G06 T01 T02 T07 T08 T10 | 0.96 | 24 | Y | N | ||
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Other methods of assessment | 10.00% | 0.00% | |
| Practicum and practical activities reports assessment | 2.50% | 2.50% | |
| Assessment of problem solving and/or case studies | 17.50% | 0.00% | |
| Final test | 70.00% | 97.50% | |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:Evaluation criteria not defined
-
Non-continuous evaluation:Evaluation criteria not defined
Specifications for the resit/retake exam:
Evaluation criteria not defined
Specifications for the second resit / retake exam:
Evaluation criteria not defined
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
10. Bibliography and Sources
| Author(s) | Title | Book/Journal | Citv | Publishing house | ISBN | Year | Description | Link | Catálogo biblioteca |
|---|---|---|---|---|---|---|---|---|---|
| A Gaw, RA Cowan, DSJ O'Reilly, MJ Stewart, J Shepherd | Bioquímica Clínica | Madrid | Harcourt | 2001 | Bibliografía complementaria | ||||
| Brown, T.A. | Genomas | Panamericana | 9500614480 | 2008 | Bibliografía complementaria | http://www.ncbi.nlm.nih.gov/books/NBK21128/ | |||
| Cox TM. y Sinclair J. | Biología Molecular en Medicina | Médica Panamericana, | 84-7903-403-3 | 1998 | Bibliografía complementaria |
|
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| David L. Nelson, Michael M.Cox | Lehninger. Principios de Bioquímica | Omega | 978-84-282-1486-5 | Bibliografía complementaria |
|
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| González de Buitrago J.M. y Medina J.M. | Patología Molecular | McGraw-Hill Interamericana | 84-486-0336-2 | 2001 | Bibliografía básica |
|
|||
| Griffiths, Anthony J. F. | Genética | McGraw-Hill | 8448603680 | 2010 | Bibliografía complementaria Genética | ||||
| J. Luque y A. Herráez | Texto Ilustrado de Biología Molecular e Ingeniería Genética. Conceptos, técnicas y aplicaciones en ciencias de la salud. | Ediciones Harcourt, Madrid | 84-8174-505-7 | 2001 | Bibliografía complementaria | ||||
| John w. Baynes. Marek H. Dominiczak | Bioquimica Médica | Elsevier | 84-8174-866-8 | 2006 | Bibliografía básica | ||||
| Scriver, CR, Beaudet AL, Sly WS, y Valle D. | The Metabolic and Molecular Bases of Inherited Disease | New York | McGraw-Hill | 2001 | Bibliografía Complementaria | ||||
| Strachan T and Read AP | Human Molecular Genetics 5º Edición | Libro | Garland Science | 9780815345893 | 2019 | Bibliografía Básica | |||
| Strachan T y Read AP. | Genética Humana | McGraw-Hill Interamericana, | 2006 | Bibliografía básica (castellano) | http://www.ncbi.nlm.nih.gov/books/NBK7580/ | ||||
| Strachan T y Read AP. | Human Molecular Genetics 4th Edition | London | Garland Science, Taylor & Francis Group. | 2010 | Bibliografía complementaria | ||||
| Sudbery P. | Genética molecular humana | Madrid | Pearson Educación | 84-205- 4252-0 | 2004 | Bibliografía básica | |||
| T. M. Devlin | Bioquímica: Libro de Texto con aplicaciones clínicas | Editorial Reverté | 84-291-7208-4 | 2004 | Bibliografía complementaria |