1. General information
Course:
EVOLUTIONARY AND REGENERATIVE MEDICINE
Code:
34342
Type:
ELECTIVE
ECTS credits:
6
Degree:
331 - UNDERGRADUATE DEGREE PROGRAMME IN MEDICINE
Academic year:
2023-24
Center:
10 - FACULTY OF MEDICINE OF ALBACETE
Group(s):
10
Year:
3
Duration:
C2
Main language:
Spanish
Second language:
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
JOSE DANIEL AROCA AGUILAR
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Área de Genética, Facultad de Medicina AB
CIENCIA Y TECNOLOGÍA AGROFORESTAL Y GENÉTICA
926053263
josedaniel.aroca@uclm.es
Lecturer:
JULIO ESCRIBANO MARTINEZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Área de Genética, Facultad de Medicina AB
CIENCIA Y TECNOLOGÍA AGROFORESTAL Y GENÉTICA
967599323
julio.escribano@uclm.es
Lecturer:
JESÚS JOSÉ FERRE FERNÁNDEZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Área de Genética, Facultad de Medicina AB
CIENCIA Y TECNOLOGÍA AGROFORESTAL Y GENÉTICA
26053263
Jesus.Ferre@uclm.es
Lecturer:
SILVIA LLORENS FOLGADO
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Medicina AB/Área de Fisiología
CIENCIAS MÉDICAS
926053634
silvia.llorens@uclm.es
Lecturer:
MONICA MUÑOZ LOPEZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Medicina/Área Anatomía
CIENCIAS MÉDICAS
926053258
monica.munozlopez@uclm.es
2. Pre-Requisites
In order to pass the subject, the student must have passed the subjects that appear in the incompatibilities chart on the website of the Faculty of Medicine of Albacete (http://blog.uclm.es/medicinaab/docencia/tabla-de- incompatibilities/).
3. Justification in the curriculum, relation to other subjects and to the profession
Evolution is the fundamental principle that organizes all of biology. In addition, it allows the integration of biological and biomedical sciences, providing the bases for understanding the function of an organism and its relationship with the physical, social and biological environment that surrounds it. Therefore, to achieve an adequate understanding of human biology, health and disease, it is necessary to know the principles of evolution and how it has shaped biological and biomedical processes at the individual and population level. These issues are clearly appreciated in the biological sciences in general, yet medicine has been slow to recognize the importance of evolution as a fundamental science in supporting knowledge of health and disease. Traditional medical thought associates health with the normal state and disease with abnormality.
The evolutionary lens qualifies this vision by contextualizing it, so that a successful adaptation in a certain environment, and therefore normal, can become something abnormal, a cause of disease, in a different environment.
On the other hand, it is important that the Medicine student knows the scientific and technical foundations of in vitro culture of cells and tissues since they constitute the basis of cell therapy and Regenerative Medicine, paying special attention to the advances that occur in the field of both embryonic and adult stem cells. Training in this discipline is complemented by the study of specific and updated applications in the treatment of pathologies that affect different organs and tissues.
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| CT01 | Mastery of a second foreign language at level B1 of the Common European Framework of Reference for Languages. |
| CT02 | Knowledge of Information and Communication Technologies (ICT). |
| CT03 | Correct oral and written communication. |
| CT04 | Ethical commitment and professional ethics. |
| G04 | Develop professional practice with respect to patient autonomy, beliefs and culture. |
| G05 | Recognise the limitations themselves and the need to maintain and update their professional competence, with particular emphasis on autonomous learning of new knowledge and techniques and motivation for quality. |
| G07 | Understand and recognise the normal structure and function of the human body, at the molecular, cellular, tissue, organic and systems levels, in the different stages of life and in the two sexes. |
| G10 | Understand and recognise the causative agents and risk factors that determine the health status and development of the disease. |
| G11 | Understand and recognise the effects of growth, development and ageing on the individual and his/her social environment. |
| G12 | Understand the fundamentals of action, indications and efficacy of therapeutic interventions, based on available scientific evidence. |
| G25 | Recognise the determinants of health in the population, both genetic and those dependent on sex and lifestyle, demographic, environmental, social, economic, psychological and cultural. |
| G26 | Assume its role in actions to prevent and protect against diseases, injuries or accidents, and to maintain and promote health, both at individual and community level. |
| G28 | Obtain and use epidemiological data and assess trends and risks for health decision-making. |
| G31 | Knowing, critically evaluating and knowing how to use the sources of clinical and biomedical information to obtain, organise, interpret and communicate scientific and health information. |
| G32 | Know how to use information and communication technologies in clinical, therapeutic, preventive and research activities. |
| G34 | To have, in the professional activity, a critical, creative point of view, with constructive skepticism and research oriented. |
| G35 | Understand the importance and limitations of scientific thinking in the study, prevention and management of diseases. |
| G36 | Be able to formulate hypotheses, collect and critically evaluate information for problem solving, following the scientific method. |
| G37 | Acquire the basic training for the research activity. |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| Understanding the health and disease of the human species from an evolutionary perspective. | |
| Knowledge of the conceptual and scientific bases of cell and tissue culture, their manipulation and therapeutic applications. | |
| Additional outcomes | |
| Not established. |
6. Units / Contents
-
Unit 1: INTRODUCTION TO EVOLUTIONARY THOUGHT IN MEDICINE
-
Unit 2: HISTORY AND VARIATION OF HUMAN GENES
-
Unit 3: NATURAL SELECTION AND EVOLUTIONARY CONFLICTS
-
Unit 4: NON-INFECTIOUS AND DEGENERATIVE DISEASES
-
Unit 5: INFECTIOUS DISEASES
-
Unit 6: CANCER
-
Unit 7: EVOLUTIONARY ORIGIN OF CELLULAR AND TISSUE REGENERATION
-
Unit 8: TYPES AND APPLICATIONS OF TISSUE CULTURE
-
Unit 9: EMBRYONIC STEM CELLS
-
Unit 10: ADULT STEM CELLS
-
Unit 11: CELL THERAPY
-
Unit 12: TISSUE ENGINEERING
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Lectures | 1.4 | 35 | Y | N | Participatory master class. Group work and discussion. Study of objectives and problem solving. | ||
| Class Attendance (practical) [ON-SITE] | Practical or hands-on activities | 0.04 | 1 | Y | Y | Laboratory practical classes | ||
| Project or Topic Presentations [ON-SITE] | Guided or supervised work | 0.72 | 18 | Y | N | Presentation and discussion of supervised works. | ||
| Study and Exam Preparation [OFF-SITE] | Self-study | 3.6 | 90 | Y | N | Study of the contents of the participatory master class and problem solving. | ||
| Other on-site activities [ON-SITE] | Assessment tests | 0.24 | 6 | Y | N | Phase V: Progress tests: 2 multiple choice test exams | ||
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Progress Tests | 50.00% | 0.00% | 2 multiple choice test exams |
| Oral presentations assessment | 30.00% | 30.00% | Presentation of a tutored work on an assigned topic and related to the subject taught. |
| Assessment of active participation | 20.00% | 0.00% | Assessment of the use in class and the participation of the student in debates and resolution of questions. |
| Final test | 0.00% | 70.00% | Short answers and essay exam. |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:To pass the subject in the ordinary call it will be necessary to obtain at least 50 points out of a total of 100 distributed in three partial exams (50 points), the oral presentation of a tutored bibliographical work (30 points) in which the memory will also be valued written, according to the indications available in Moodle, and the assessment of class participation (20 points). Participation will be valued mainly through discussion, debate and ability to argue the issues raised by both students and teachers. In the classes, questions will be raised about the different parts of the subject that will be briefly debated by the students organized in small groups and later discussed with the rest of the class.
-
Non-continuous evaluation:For the non-continuous evaluation, the items and its values indicated for the different parts of the subject will be applied.
*Chapter III. Art. 4.2 b) Any student may change to the non-continuous evaluation modality, by the procedure established by the Center, provided that they have not participated during the class period.
in evaluable activities that together account for at least 50% of the total evaluation of the subject. If a student has reached that 50% of evaluable activities or if, in any case, the class period has ended, they will be considered in continuous evaluation without the possibility of changing the evaluation modality.
Specifications for the resit/retake exam:
Those students who has not reached 50 points in the ordinary call may recover the parts not passed in a PEM type exam. The points obtained in the tests of the ordinary call will be kept for the final call for a maximum of two academic years.
Specifications for the second resit / retake exam:
*The same criteria will be followed as for the extraordinary call of the previous course, as stated in the corresponding teaching guides (Art. 13.3. Student Assessment Regulations). This call may be used by students who are in the cases indicated in the Student Assessment Regulations in force (currently, Art. 13.1).
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
| Other on-site activities [PRESENCIAL][Assessment tests] | 6 |
| Unit 1 (de 12): INTRODUCTION TO EVOLUTIONARY THOUGHT IN MEDICINE | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 2 (de 12): HISTORY AND VARIATION OF HUMAN GENES | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 3 (de 12): NATURAL SELECTION AND EVOLUTIONARY CONFLICTS | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 4 (de 12): NON-INFECTIOUS AND DEGENERATIVE DISEASES | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 5 (de 12): INFECTIOUS DISEASES | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 6 (de 12): CANCER | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 7 (de 12): EVOLUTIONARY ORIGIN OF CELLULAR AND TISSUE REGENERATION | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 8 (de 12): TYPES AND APPLICATIONS OF TISSUE CULTURE | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 2 |
| Class Attendance (practical) [PRESENCIAL][Practical or hands-on activities] | 1 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 9 (de 12): EMBRYONIC STEM CELLS | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 10 (de 12): ADULT STEM CELLS | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 11 (de 12): CELL THERAPY | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Unit 12 (de 12): TISSUE ENGINEERING | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 3 |
| Project or Topic Presentations [PRESENCIAL][Guided or supervised work] | 1.5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 7.5 |
| Global activity | |
|---|---|
| Activities | hours |
10. Bibliography and Sources
