Guías Docentes Electrónicas
1. General information
Course:
BIOCHEMISTRY
Code:
57328
Type:
CORE COURSE
ECTS credits:
6
Degree:
409 - CHEMISTRY
Academic year:
2022-23
Center:
1 - FACULTY OF SCIENCE AND CHEMICAL TECHNOLOGY
Group(s):
20 
Year:
4
Duration:
First quarter
Main language:
Spanish
Second language:
English
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer: MARGARITA VILLAR RAYO - Group(s): 20 
Building/Office
Department
Phone number
Email
Office hours
Facultad de Ciencias y Tecnologías Químicas/ 3ª planta
QUÍMICA INORG., ORG., Y BIOQ.
926052530
MargaritaM.Villar@uclm.es
Mon, Tues, Wed from 10 a.m. to 12 a.m. Check in advance by email.

2. Pre-Requisites

Basic module.

3. Justification in the curriculum, relation to other subjects and to the profession

This matter is part of a supplementary module in the degree in chemistry.

It is offered in the fourth year of the degree. It provides a necessary knowledge for chemical studies in relation to living beings and pharmacology. Fields of application of Biochemistry to a graduate in chemistry are clinical tests, pharmaceutical industry, biomedical research, biotechnology and certain applications of nanotechnology, among others.

On the other hand, the subject of Biochemistry requires the foundations acquired in the first course of biology, as well as basic aspects of chemical reactions kinetics and thermodynamics.


4. Degree competences achieved in this course
Course competences
Code Description
CB03 Be able to gather and process relevant information (usually within their subject area) to give opinions, including reflections on relevant social, scientific or ethical issues.
CB05 Have developed the necessary learning abilities to carry on studying autonomously
E12 Understand the chemistry of the main biological processes
G02 Be able to gather and interpret data, information and relevant results, obtain conclusions and issue reasoned reports on scientific, technological or other problems that require the use of chemical tools
G03 Know how to apply the theoretical-practical knowledge acquired in the different professional contexts of Chemistry
T03 Proper oral and written communication
T05 Organization and planning capacity
T11 Ability to obtain bibliographic information, including Internet resources
5. Objectives or Learning Outcomes
Course learning outcomes
Description
Be able to make a general scheme of carbohydrate metabolism, locating the main routes involved, as well as their functions
Be able to make a general scheme that relates the tricarboxylic acid cycle with the metabolism of carbohydrates, lipids and amino acids and with the chain of electronic transport and oxidative phosphorylation
Understand the physiological importance of the generation of ketone bodies
Know how the expression of genes is regulated depending on the cellular and body needs
Knowing how to explain the differences between the routes of ¿-oxidation and fatty acid synthesis and knowing the main mechanisms involved in its regulation
Be able to describe the Calvin cycle and other alternative CO2 fixation routes
Be able to describe the nitrogen cycle in the biosphere
Be able to describe the ATP synthesis mechanism coupled to electronic transport
Be able to describe the molecular mechanism of replication, transcription and translation
Be able to describe the photosystems and electronic transporters that participate in the light reactions of photosynthesis
Be able to explain the specific functions of different organs in the whole metabolism
Be able to make a comparative analysis of photophosphorylation and oxidative phosphorylation, indicating the similarities and differences between both processes of ATP synthesis
Be able to interpret a michaelian enzymatic kinetics, calculate the parameters of Km and Vmax, and distinguish these kinetics from allosteric kinetics
Know the basic mechanisms of metabolic regulation
Know various alterations of energy metabolism
Know the global scheme of synthesis and degradation of nucleotides
Know the general strategy of protein and amino acid catabolism, as well as the urea cycle
Know the practical applications of DNA technology
Additional outcomes
Description
Know the general chart of plasma lipoprotein and cholesterol metabolism.
6. Units / Contents
  • Unit 1: Introduction to metabolism
  • Unit 2: Enzymatic catalysis and its regulation
  • Unit 3: Carbohydrate metabolism
  • Unit 4: Photosynthesis
  • Unit 5: Lipid metabolism
  • Unit 6: Metabolism of nitrogenous compounds
  • Unit 7: Integration and hormonal regulation of metabolism
  • Unit 8: Expression and transmission of genetic information
7. Activities, Units/Modules and Methodology
Training Activity Methodology Related Competences ECTS Hours As Com Description
Class Attendance (theory) [ON-SITE] Lectures CB03 CB05 E12 1.2 30 N N The most relevant information on the agenda is presented. To encourage participation, mobile phones may be used as audience response systems.
Laboratory practice or sessions [ON-SITE] Practical or hands-on activities CB03 CB05 E12 G02 G03 T05 0.48 12 Y Y Experimental procedures will be carried out in the laboratory directly related to some of the theoretical content. Laboratory practices are mandatory and non-recoverable. If they are not realized, the subject cannot be passed.
Group tutoring sessions [ON-SITE] Group tutoring sessions CB03 CB05 E12 G02 0.02 0.5 N N The aim of this activity is to clarify doubts related to theoretical contents and laboratory practices.
Workshops or seminars [ON-SITE] Combination of methods CB03 CB05 E12 G02 G03 T03 T05 T11 0.5 12.5 Y N Different activities are proposed, such as the resolution of problems or cases, which will contribute to completing and consolidating the contents of the subject.
Progress test [ON-SITE] Assessment tests CB03 CB05 E12 G02 G03 T03 T05 T11 0.2 5 Y N A progress test of the contents taught in the laboratory practices and another with part of the theoretical contents will be carried out. The dates will be available well in advance on the virtual campus. In addition, there will be a final test that will coincide with the date of the ordinary call. A progress test of the contents taught in the laboratory practices and another with part of the theoretical contents will be carried out. The dates will be available well in advance on the virtual campus. In addition, there will be a final test that will coincide with the date of the ordinary call.
Study and Exam Preparation [OFF-SITE] Self-study CB03 CB05 E12 G02 G03 T05 T11 3.6 90 N N Preparation of the different evaluation tests.
Total: 6 150
Total credits of in-class work: 2.4 Total class time hours: 60
Total credits of out of class work: 3.6 Total hours of out of class work: 90

As: Assessable training activity
Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).

8. Evaluation criteria and Grading System
Evaluation System Continuous assessment Non-continuous evaluation * Description
Test 15.00% 15.00% Exam on the laboratory practices content
Assessment of problem solving and/or case studies 25.00% 25.00% The students will solve problems and cases that will be treated in the seminars. Part of the activity and its evaluation will be in small groups and part individually.
Final test 60.00% 60.00% Final test consisting of an exam that includes all the contents taught in the subject
Total: 100.00% 100.00%  
According to art. 6 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 13.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).

Evaluation criteria for the final exam:
  • Continuous assessment:
    Based on minimal knowledge of Biochemistry terminology and on basic concepts, mainly the ability to relate data and processes, reasoning capacity and synthesis capacity will be assessed in all evaluation exercises conducted throughout the course.
    To average different tests, a minimun of 4 out to 10 in any of the evaluated items will be required, although to pass the subject, the student must obtain a minimum global grade of 5 out of 10.
  • Non-continuous evaluation:
    In the case of choosing the non-continuous evaluation, the students will take a single final test that will evaluate 100% of the skills, including, in addition to the theoretical content, the practice test and the resolution of problems or cases.
    To average different tests, a minimun of 4 out to 10 in any of the evaluated items will be required, although to pass the subject, the student must obtain a minimum global grade of 5 out of 10.

Specifications for the resit/retake exam:
The evaluation criteria of the final exam will be maintained.
The student who has obtained, at least, a grade of 4 out of 10, in the tests carried out in the final exam, may choose to maintain the grade obtained or re-evaluate its contents, although only it will be understood that the subject has been passed if the student has obtained a minimum average of 5 out of 10 in the global average.
Specifications for the second resit / retake exam:
Same as resit exam.
9. Assignments, course calendar and important dates
Not related to the syllabus/contents
Hours hours
Class Attendance (theory) [PRESENCIAL][Lectures] 30
Laboratory practice or sessions [PRESENCIAL][Practical or hands-on activities] 12
Group tutoring sessions [PRESENCIAL][Group tutoring sessions] .5
Workshops or seminars [PRESENCIAL][Combination of methods] 12.5
Progress test [PRESENCIAL][Assessment tests] 5
Study and Exam Preparation [AUTÓNOMA][Self-study] 90

Global activity
Activities hours
General comments about the planning: Laboratory practices will be adapted, depending on the restrictions imposed by the regulations related to covid-19 at the time of their completion. In the case of the number of laboratory hours reduced, these will be replaced by other activities.
10. Bibliography and Sources
Author(s) Title Book/Journal Citv Publishing house ISBN Year Description Link Catálogo biblioteca
Feduchi E., Romero C., Yáñez E. y García-Hoz, C. Bioquímica. Conceptos esenciales. 3ª Ed. Ed. Médica Panamericana 978-84-9110-680-7 2021  
Mathews C.K. , van Holde K.E. y Ahern K.G Bioquímica Madrid Pearson Educación, S.A. 0-80533066-6 2002  
Nelson D.L., Cox M.M. Lehninger Principios de Bioquímica Ediciones Omega S.A. 978-84-282-1486-5 2009 Ficha de la biblioteca
Nelson D.L., Cox M.M. Lehninger Principles of Biochemistry 7th ed. Book Hamilton, N.J. W.H. Freeman. MacMillan Learning. 9781464126116 2017  
Stryer L., Berg J., y Tymoczko J. Bioquímica Barcelona Editorial Reverté 9788429176025 2013  
Voet D. y Voet J.G. Bioquímica Buenos Aires Ed. Médica Panamericana 950-06-2301-3 2006  
Voet D., Voet J., Pratt C. Fundamentals of Biochemistry: Life at the Molecular Level, 5th Edition Book John Wiley & Sons, Inc. 978-1118918401 2016  



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