1. General information
Course:
BIOCHEMISTRY
Code:
57328
Type:
CORE COURSE
ECTS credits:
6
Degree:
409 - CHEMISTRY
Academic year:
2022-23
Center:
1 - FACULTY OF SCIENCE AND CHEMICAL TECHNOLOGY
Group(s):
20
Year:
4
Duration:
First semester
Main language:
Spanish
Second language:
English
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
MARGARITA VILLAR RAYO
- Group(s):
20
Building/Office
Department
Phone number
Email
Office hours
Facultad de Ciencias y Tecnologías Químicas/ 3ª planta
QUÍMICA INORG., ORG., Y BIOQ.
926052530
MargaritaM.Villar@uclm.es
Mon, Tues, Wed from 10 a.m. to 12 a.m. Check in advance by email.
2. Pre-Requisites
Basic module.
3. Justification in the curriculum, relation to other subjects and to the profession
This matter is part of a supplementary module in the degree in chemistry.
It is offered in the fourth year of the degree. It provides a necessary knowledge for chemical studies in relation to living beings and pharmacology. Fields of application of Biochemistry to a graduate in chemistry are clinical tests, pharmaceutical industry, biomedical research, biotechnology and certain applications of nanotechnology, among others.
On the other hand, the subject of Biochemistry requires the foundations acquired in the first course of biology, as well as basic aspects of chemical reactions kinetics and thermodynamics.
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| CB03 | Be able to gather and process relevant information (usually within their subject area) to give opinions, including reflections on relevant social, scientific or ethical issues. |
| CB05 | Have developed the necessary learning abilities to carry on studying autonomously |
| E12 | Understand the chemistry of the main biological processes |
| G02 | Be able to gather and interpret data, information and relevant results, obtain conclusions and issue reasoned reports on scientific, technological or other problems that require the use of chemical tools |
| G03 | Know how to apply the theoretical-practical knowledge acquired in the different professional contexts of Chemistry |
| T03 | Proper oral and written communication |
| T05 | Organization and planning capacity |
| T11 | Ability to obtain bibliographic information, including Internet resources |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| Be able to make a general scheme of carbohydrate metabolism, locating the main routes involved, as well as their functions | |
| Be able to make a general scheme that relates the tricarboxylic acid cycle with the metabolism of carbohydrates, lipids and amino acids and with the chain of electronic transport and oxidative phosphorylation | |
| Understand the physiological importance of the generation of ketone bodies | |
| Know how the expression of genes is regulated depending on the cellular and body needs | |
| Knowing how to explain the differences between the routes of ¿-oxidation and fatty acid synthesis and knowing the main mechanisms involved in its regulation | |
| Be able to describe the Calvin cycle and other alternative CO2 fixation routes | |
| Be able to describe the nitrogen cycle in the biosphere | |
| Be able to describe the ATP synthesis mechanism coupled to electronic transport | |
| Be able to describe the molecular mechanism of replication, transcription and translation | |
| Be able to describe the photosystems and electronic transporters that participate in the light reactions of photosynthesis | |
| Be able to explain the specific functions of different organs in the whole metabolism | |
| Be able to make a comparative analysis of photophosphorylation and oxidative phosphorylation, indicating the similarities and differences between both processes of ATP synthesis | |
| Be able to interpret a michaelian enzymatic kinetics, calculate the parameters of Km and Vmax, and distinguish these kinetics from allosteric kinetics | |
| Know the basic mechanisms of metabolic regulation | |
| Know various alterations of energy metabolism | |
| Know the global scheme of synthesis and degradation of nucleotides | |
| Know the general strategy of protein and amino acid catabolism, as well as the urea cycle | |
| Know the practical applications of DNA technology | |
| Additional outcomes | |
| Description | |
| Know the general chart of plasma lipoprotein and cholesterol metabolism. | |
6. Units / Contents
-
Unit 1: Introduction to metabolism
-
Unit 2: Enzymatic catalysis and its regulation
-
Unit 3: Carbohydrate metabolism
-
Unit 4: Photosynthesis
-
Unit 5: Lipid metabolism
-
Unit 6: Metabolism of nitrogenous compounds
-
Unit 7: Integration and hormonal regulation of metabolism
-
Unit 8: Expression and transmission of genetic information
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Lectures | CB03 CB05 E12 | 1.2 | 30 | N | N | The most relevant information on the agenda is presented. To encourage participation, mobile phones may be used as audience response systems. | |
| Laboratory practice or sessions [ON-SITE] | Practical or hands-on activities | CB03 CB05 E12 G02 G03 T05 | 0.48 | 12 | Y | Y | Experimental procedures will be carried out in the laboratory directly related to some of the theoretical content. Laboratory practices are mandatory and non-recoverable. If they are not realized, the subject cannot be passed. | |
| Group tutoring sessions [ON-SITE] | Group tutoring sessions | CB03 CB05 E12 G02 | 0.02 | 0.5 | N | N | The aim of this activity is to clarify doubts related to theoretical contents and laboratory practices. | |
| Workshops or seminars [ON-SITE] | Combination of methods | CB03 CB05 E12 G02 G03 T03 T05 T11 | 0.5 | 12.5 | Y | N | Different activities are proposed, such as the resolution of problems or cases, which will contribute to completing and consolidating the contents of the subject. | |
| Progress test [ON-SITE] | Assessment tests | CB03 CB05 E12 G02 G03 T03 T05 T11 | 0.2 | 5 | Y | N | A progress test of the contents taught in the laboratory practices and another with part of the theoretical contents will be carried out. The dates will be available well in advance on the virtual campus. In addition, there will be a final test that will coincide with the date of the ordinary call. A progress test of the contents taught in the laboratory practices and another with part of the theoretical contents will be carried out. The dates will be available well in advance on the virtual campus. In addition, there will be a final test that will coincide with the date of the ordinary call. | |
| Study and Exam Preparation [OFF-SITE] | Self-study | CB03 CB05 E12 G02 G03 T05 T11 | 3.6 | 90 | N | N | Preparation of the different evaluation tests. | |
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Test | 15.00% | 15.00% | Exam on the laboratory practices content |
| Assessment of problem solving and/or case studies | 25.00% | 25.00% | The students will solve problems and cases that will be treated in the seminars. Part of the activity and its evaluation will be in small groups and part individually. |
| Final test | 60.00% | 60.00% | Final test consisting of an exam that includes all the contents taught in the subject |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:Based on minimal knowledge of Biochemistry terminology and on basic concepts, mainly the ability to relate data and processes, reasoning capacity and synthesis capacity will be assessed in all evaluation exercises conducted throughout the course.
To average different tests, a minimun of 4 out to 10 in any of the evaluated items will be required, although to pass the subject, the student must obtain a minimum global grade of 5 out of 10. -
Non-continuous evaluation:In the case of choosing the non-continuous evaluation, the students will take a single final test that will evaluate 100% of the skills, including, in addition to the theoretical content, the practice test and the resolution of problems or cases.
To average different tests, a minimun of 4 out to 10 in any of the evaluated items will be required, although to pass the subject, the student must obtain a minimum global grade of 5 out of 10.
Specifications for the resit/retake exam:
The evaluation criteria of the final exam will be maintained.
The student who has obtained, at least, a grade of 4 out of 10, in the tests carried out in the final exam, may choose to maintain the grade obtained or re-evaluate its contents, although only it will be understood that the subject has been passed if the student has obtained a minimum average of 5 out of 10 in the global average.
The student who has obtained, at least, a grade of 4 out of 10, in the tests carried out in the final exam, may choose to maintain the grade obtained or re-evaluate its contents, although only it will be understood that the subject has been passed if the student has obtained a minimum average of 5 out of 10 in the global average.
Specifications for the second resit / retake exam:
Same as resit exam.
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 30 |
| Laboratory practice or sessions [PRESENCIAL][Practical or hands-on activities] | 12 |
| Group tutoring sessions [PRESENCIAL][Group tutoring sessions] | .5 |
| Workshops or seminars [PRESENCIAL][Combination of methods] | 12.5 |
| Progress test [PRESENCIAL][Assessment tests] | 5 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 90 |
| Global activity | |
|---|---|
| Activities | hours |
| General comments about the planning: | Laboratory practices will be adapted, depending on the restrictions imposed by the regulations related to covid-19 at the time of their completion. In the case of the number of laboratory hours reduced, these will be replaced by other activities. |
10. Bibliography and Sources
