1. General information
Course:
PHARMACEUTICAL CHEMISTRY II
Code:
14324
Type:
CORE COURSE
ECTS credits:
6
Degree:
376 - UNDERGRADUATE DEGREE PROGRAMME IN PHARMACY
Academic year:
2022-23
Center:
14 - FACULTY OF PHARMACY
Group(s):
10
Year:
3
Duration:
C2
Main language:
Spanish
Second language:
English
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
JOAQUIN CALIXTO GARCIA MARTINEZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia
QUÍMICA INORG., ORG., Y BIOQ.
+34926053224
joaquinc.garcia@uclm.es
Lecturer:
ANTONIO SANCHEZ RUIZ
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia
QUÍMICA INORG., ORG., Y BIOQ.
+34926052974
Antonio.SanchezRuiz@uclm.es
Lecturer:
ANA MARÍA SOUSA HERVÉS
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia
QUÍMICA INORG., ORG., Y BIOQ.
+34926052919
Ana.Sousa@uclm.es
Lecturer:
JUAN TOLOSA BARRILERO
- Group(s):
10
Building/Office
Department
Phone number
Email
Office hours
Facultad de Farmacia
QUÍMICA INORG., ORG., Y BIOQ.
2238
juan.tolosa@uclm.es
2. Pre-Requisites
No prerequisites are established for this subject although it is recommended that the student has previously passed the subjects of Organic Chemistry I and II, Biochemistry I and II, Physical Chemistry I and II and Pharmaceutical Chemistry I.
3. Justification in the curriculum, relation to other subjects and to the profession
Pharmaceutical Chemistry is the discipline responsible for the design, synthesis and development of molecules with biological activity and drugs for therapeutic purposes. In this sense, this subject is very important in the training of graduates in pharmacy. This is a subject that requires a solid previous knowledge of organic chemistry, biochemistry and physico-chemistry, and the knowledge acquired from it will be used in subjects such as pharmacology, bioinformatics, biopharmacy and pharmacokinetics, among others.
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| B01 | Proficiency in a second foreign language at level B1 of the Common European Framework of Reference for Languages. |
| B02 | Knowledge of Information and Communication Technologies (ICT). |
| B03 | A correct oral and written communication |
| B04 | Ethical commitment and professional deontology. |
| B05 | Ability to develop those learning skills necessary to undertake further studies. |
| EQ01 | Identify, design, prepare, analyse and produce active principles, drugs and other materials and products of sanitary interest. |
| EQ03 | Complete standard laboratory processes including the employment of scientific equipment related to synthesis and analysis. |
| EQ04 | Evaluate risks/hazards associated to the use of chemical substances and lab processes. |
| G01 | Identify, design, obtain, analyze, control and produce drugs and medicines, as well as other products and raw materials of sanitary interest for human or veterinary use. |
| G02 | Evaluate the therapeutic and toxic effects of substances with pharmacological activity. |
| G03 | Know how to apply the scientific method and acquire skills in the handling of legislation, sources of information, bibliography, elaboration of protocols and other aspects considered necessary for the design and critical evaluation of preclinical and clinical trials. |
| G04 | Design, prepare, supply and dispense medicines and other products of health interest. |
| G05 | Provide therapeutic advice in pharmacotherapy and dietotherapy, as well as in the nutritional and food field in the establishments where they provide services. |
| G06 | Promote the rational use of medicines and medical devices, as well as to acquire basic knowledge in clinical management, health economics and the efficient use of health resources. |
| G07 | Identify, evaluate and assess problems related to drugs and medicines, as well as participate in pharmacovigilance activities. |
| G08 | Conducting clinical and social pharmacy activities, following the pharmaceutical care cycle. |
| G09 | Intervene in health promotion and disease prevention activities at the individual, family and community levels, with an integral and multi-professional vision of the health-disease process. |
| G10 | Design, apply and evaluate clinical reagents, methods and analytical techniques, knowing the basic principles of clinical analysis and the characteristics and contents of laboratory diagnostic reports. |
| G11 | Evaluate the toxicological effects of substances and design and apply appropriate tests and trials. |
| G12 | Develop hygienic-sanitary analyses, especially those related to food and environment. |
| G13 | Develop communication and information skills, both oral and written, to deal with patients and users of the centre where they carry out their professional activity. Promote the capacity to work and collaborate with multidisciplinary teams and those related to other health professionals. |
| G14 | Know the ethical and deontological principles according to the legislative, regulatory and administrative provisions governing professional practice, understanding the ethical implications of health in a changing social context. |
| G15 | Recognise own limitations and the need to maintain and update professional competence, with particular emphasis on self-learning of new knowledge based on scientific evidence. |
| T01 | Critical thinking skills based on the application of the scientific method |
| T02 | Ability to manage quality scientific information, bibliography, specialized databases and resources accessible through the Internet. |
| T03 | Handling of basic and specific software for the treatment of information and experimental results. |
| T04 | Motivation for quality, safety at work and awareness of environmental issues, with knowledge of the internationally recognised systems for the correct management of these aspects. |
| T05 | Organizational, planning and implementation skills. |
| T06 | Ability to address human resources decision-making and management. |
| T07 | Ability to work as a team and, where appropriate, exercise leadership functions, encouraging entrepreneurship. |
| T08 | Develop interpersonal skills and the ability to function in an international and multicultural context. |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| Acquisition of basic skills in synthesis and analytical characterization of drugs in a practical level. | |
| Ability to find and analyze scientific information regarding the chemical aspects of drugs. | |
| ability to associate the structure of drugs with their mechanism of action and their therapeutic activity at the molecular level. | |
| ability to define the pharmacophore group of a set of active molecules. | |
| ability to design synthetic routes to prepare drugs | |
| ability to propose chemical transformations of drugs aimed at optimizing their pharmacokinetic properties and their biological activity. | |
| ability to predict the metabolic transformations suffered by drugs inside the body. | |
| ability to name drugs and to represent their structure from the systematic nomenclature | |
| Additional outcomes | |
| Not established. |
6. Units / Contents
-
Unit 1: Chemotherapy enzyme inhibitors I
-
Unit 1.1: Inhibitors related with folic acid
-
Unit 1.2: Inhibitors of purines and pyrimidines synthesis
-
Unit 1.3: Inhibitors related with polymeration of nucleic acid
-
Unit 1.4: Inhibitors of neuraminidase
-
Unit 1.5: Synthesis
-
-
Unit 2: Chemotherapy enzyme inhibitors II. Penicillin and Cephalosporins
-
Unit 2.1: Inhibitors of Biosynthesis of UDP-N-Acetylmuramoil pentapeptide
-
Unit 2.2: Inhibitors of 2nd and 3er stage of synthesis of peptidoglycan
-
Unit 2.3: Inhibitors of 4th stage of synthesis os peptidoglycan
-
Unit 2.4: Synthesis
-
-
Unit 3: Pharmacodinamic enzime Inhibitors
-
Unit 3.1: Inhibitors of Angiotensin-converting enzyme
-
Unit 3.2: Inhibitors of GABA-T
-
Unit 3.3: Inhibitos of carbonic anhydrases
-
Unit 3.4: Inhibitors of cyclooxigenase
-
Unit 3.5: Synthesis
-
-
Unit 4: Drugs related to transport through the membrane
-
Unit 4.1: Drug that acts on Na+ channels
-
Unit 4.2: Drugs regulators of Ca+ channels
-
Unit 4.3: Drugs that acts on K+ channes
-
Unit 4.4: Inhibitors of H+/K+ ATPase
-
Unit 4.5: Synthesis
-
-
Unit 5: Drugs related to the activity of noradrenaline, dopamine, and serotonin
-
Unit 5.1: Adrenalergic drugs
-
Unit 5.2: Dopaminergic drugs
-
Unit 5.3: Serotoninergic drugs
-
Unit 5.4: Synthesis
-
-
Unit 6: Drugs related to the activity of acetylcholine
-
Unit 6.1: Cholinergic Receptors and supramolecular interactions
-
Unit 6.2: Clinic used of acetylcholine drugs
-
Unit 6.3: Synthesis
-
-
Unit 7: Drugs related to peptides and aminoacid receptors
-
Unit 7.1: GABA-receptors related drugs
-
Unit 7.2: Glutamic receptors related drugs
-
Unit 7.3: Peptides receptors related drugs
-
Unit 7.4: Synthesis
-
-
Unit 8: Drugs that acts on histamine receptors
-
Unit 8.1: H1 Antagonist
-
Unit 8.2: H2 Antagonist
-
Unit 8.3: synthesis
-
-
Unit 9: Drugs related to the activation of steroid hormons
-
Unit 10: Drugs related to nucleic acid
-
Unit 10.1: Alkylanting, intercalating, and non-covalent DNA union agents
-
Unit 10.2: Tetracyclines
-
-
Unit 11: Laboratory Practices
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Combination of methods | B01 B02 B03 B04 B05 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.92 | 23 | Y | N | ||
| Class Attendance (practical) [ON-SITE] | Practical or hands-on activities | B01 B02 B03 B04 B05 EQ01 EQ03 EQ04 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.8 | 20 | Y | Y | ||
| Workshops or seminars [ON-SITE] | Combination of methods | B01 B02 B03 B04 B05 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.52 | 13 | Y | N | ||
| Study and Exam Preparation [OFF-SITE] | Self-study | B01 B02 B03 B04 B05 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 2.07 | 51.75 | Y | N | ||
| Study and Exam Preparation [OFF-SITE] | Problem solving and exercises | B01 B02 B03 B04 B05 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 1.53 | 38.25 | Y | N | ||
| Formative Assessment [ON-SITE] | Assessment tests | B01 B02 B03 B04 B05 G01 G02 G03 G04 G05 G06 G07 G08 G09 G10 G11 G12 G13 G14 G15 T01 T02 T03 T04 T05 T06 T07 T08 | 0.16 | 4 | Y | Y | ||
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Assessment of active participation | 10.00% | 10.00% | |
| Test | 70.00% | 70.00% | |
| Laboratory sessions | 20.00% | 20.00% | |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:Evaluation criteria not defined
-
Non-continuous evaluation:Evaluation criteria not defined
Specifications for the resit/retake exam:
Evaluation criteria not defined
Specifications for the second resit / retake exam:
Evaluation criteria not defined
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
| Class Attendance (theory) [PRESENCIAL][Combination of methods] | 23 |
| Class Attendance (practical) [PRESENCIAL][Practical or hands-on activities] | 20 |
| Workshops or seminars [PRESENCIAL][Combination of methods] | 13 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 51.75 |
| Study and Exam Preparation [AUTÓNOMA][Problem solving and exercises] | 38.25 |
| Formative Assessment [PRESENCIAL][Assessment tests] | 4 |
| Global activity | |
|---|---|
| Activities | hours |
10. Bibliography and Sources
