Guías Docentes Electrónicas
1. General information
Course:
CLINICAL BIOCHEMISTRY
Code:
13323
Type:
CORE COURSE
ECTS credits:
6
Degree:
341 - UNDERGRADUATE DEGREE PROGRAMME IN BIOCHEMISTRY
Academic year:
2021-22
Center:
501 - FACULTY OF ENVIRONMENTAL SCIENCES AND BIOCHEMISTRY
Group(s):
40 
Year:
3
Duration:
C2
Main language:
Spanish
Second language:
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer: YOLANDA CAMPOS MARTIN - Group(s): 40 
Building/Office
Department
Phone number
Email
Office hours
Edificio 6/10
QUÍMICA INORG., ORG., Y BIOQ.
Yolanda.Campos@uclm.es
request by email

Lecturer: ANA ISABEL CORPS RICARDO - Group(s): 40 
Building/Office
Department
Phone number
Email
Office hours
ICAM/0.22
Q. ANALÍTICA Y TGIA. ALIMENTOS
AnaIsabel.Corps@uclm.es
Arrange an appoinment by e-mail.

Lecturer: MARIA JIMENEZ MORENO - Group(s): 40 
Building/Office
Department
Phone number
Email
Office hours
Sabatini/0.8
Q. ANALÍTICA Y TGIA. ALIMENTOS
926051710
maria.jimenez@uclm.es
Tuesday, Wednesday and Thursday from 12 to 14 h. Arrange an appointment by e-mail

Lecturer: NURIA RODRIGUEZ FARIÑAS - Group(s): 40 
Building/Office
Department
Phone number
Email
Office hours
Sabatini/0.9
Q. ANALÍTICA Y TGIA. ALIMENTOS
5459
nuria.rodriguez@uclm.es

Lecturer: ROSA DEL CARMEN RODRIGUEZ MARTIN-DOIMEADIOS - Group(s): 40 
Building/Office
Department
Phone number
Email
Office hours
Sabatini/0.16
Q. ANALÍTICA Y TGIA. ALIMENTOS
5420
rosacarmen.rodriguez@uclm.es
Monday, Tuesday and Wednesday from 13 to 14 h and from 15 to 16 h. Arrange an appointment by e-mail

2. Pre-Requisites

It is recommended to have a previous knowledge about Fundamentals of Biochemistry, Methodology and Instrumentation in Biochemistry, Molecular Pathology and Human Physiology.

3. Justification in the curriculum, relation to other subjects and to the profession

This is a mandatory subject focused on two main aspects, the analytical methodology that is usually employed for the determination of main metabolites in clinical analysis and the study of the potential metabolic alterations of these analytes and their clinical implications. 

This subject also presents the role of a biochemist in a clinical laboratory mainly related to the interpretation of clinical analysis and the detection of potential pathologies.


4. Degree competences achieved in this course
Course competences
Code Description
E01 Express themselves correctly in basic biological, physical, chemical, mathematical and computer terms.
E02 Work properly and quality driven in a chemical, biological and biochemical laboratory, including safety, handling and disposal of waste and keeping a record of activities.
E03 Understand and know how to explain the physical and chemical bases of biochemical processes and the techniques used to investigate them
E04 To know the principles and applications of the methods and instrumentation used in bioanalytical determinations.
E12 Have the numerical and computational skills to apply mathematical procedures for data analysis.
E13 Correct handling of different computer tools
E28 Calculate well the sensitivity, specificity, predictive value and efficiency of an analytical test and interpret the results obtained, with respect to the reference intervals.
E29 To interpret the results of the biochemical parameters of a blood and urine analysis, among others, suggesting the orientation of the possible underlying pathologies of the alterations found.
G01 To possess and understand the knowledge in the area of Biochemistry and Molecular Biology at a level that, based on advanced textbooks, also includes cutting-edge aspects of relevance in the discipline
G03 Be able to collect and interpret relevant data, information and results, draw conclusions and issue reasoned reports on relevant social, scientific or ethical issues in connection with advances in Biochemistry and Molecular Biology.
T01 Proficiency in a second foreign language, preferably English, at level B1 of the Common European Framework of Reference for Languages
T03 A correct oral and written communication
T05 Organizational and planning skills
T06 Capacity for design, analysis and synthesis
T08 Ability to work as a team and, where appropriate, exercise leadership functions, encouraging entrepreneurship
5. Objectives or Learning Outcomes
Course learning outcomes
Description
Interpreting the results of biochemical and cellular parameters of an analysis and suggesting possible pathologies according to the alterations found.
To know the basic applications of analytical biochemistry.
Know how to evaluate and interpret the results of the analytical parameters.
Perform the most common determinations in clinical analysis laboratories.
Understand the use of molecular biology tools to determine analytical parameters.
To apply and know the quality control methods in clinical analysis laboratories, understanding the concepts of reference interval and variation of results by analytical and biological cause.
Learn how to handle biological samples in the appropriate conditions and considering the factors that could affect the specific analysis.
Additional outcomes
Not established.
6. Units / Contents
  • Unit 1: Introduction to clinical biochemistry.
    • Unit 1.1: Introduction to clinical analysis.
    • Unit 1.2: Pre-analytical phase.
    • Unit 1.3: Analytical phase.
    • Unit 1.4: Post-analytical phase.
  • Unit 2: Analytes and metabolic pathways.
    • Unit 2.1: Hydroelectrolitic balance and its alterations. Blood gases.
    • Unit 2.2: Acid-base balance and its alterations. Biological buffer systems.
    • Unit 2.3: Study of alterations of plasma, urine and cerebrospinal fluid proteins.
    • Unit 2.4: Biochemical diagnosis and follow-un of patients with alterations in carbohydrate metabolism. Diabetes and Hipoglycemia.
    • Unit 2.5: Study of the biochemical alterations involved in the study of dyslipidemias.
    • Unit 2.6: Biochemical diagnosis of iron-related disorders.
  • Unit 3: Biochemical analysis of the function of organs and tissues.
    • Unit 3.1: Cardiac markers related to the diagnosis of acute cronary syndrome and heart failure.
    • Unit 3.2: Biochemical alterations of liver function.
    • Unit 3.3: Biochemical alterations related to gastrointestinal function.
    • Unit 3.4: Biochemical magnitudes involved in the study of renal function.
    • Unit 3.5: Hormones regulating homeostasis of calcium and phosphorus.
    • Unit 3.6: Endocrine and biochemical alterations of the hypotalamic-hypophyseal axis and hypotalamic-hypophyseal- thyroid axis.
    • Unit 3.7: Endocrine and biochemical alterations of the hypotalamic-hypophyseal-adrenal and hypotalamic-hypophyseal-gonadal axis.
    • Unit 3.8: Tumor markers used in clinical practice.
ADDITIONAL COMMENTS, REMARKS

Laboratory sessions:

- Determination of metabolites of clinical interest in biological matrices (urine and/or blood).

- Interpretation of experimental results and clinical case studies.

 


7. Activities, Units/Modules and Methodology
Training Activity Methodology Related Competences (only degrees before RD 822/2021) ECTS Hours As Com Description
Class Attendance (theory) [ON-SITE] Lectures E01 E03 E12 T01 1.54 38.5 N N The presentations to follow the teaching classes will be available at the Moodle virtual platform for download. Each presentation will indicate the objetives and the contents of each topic. Teaching classes will be developed in an interactive way with the students including open discussion.
Study and Exam Preparation [OFF-SITE] Self-study 3.2 80 N N
Class Attendance (practical) [ON-SITE] Practical or hands-on activities E02 E04 E12 E13 E28 E29 G03 T05 T06 T08 0.64 16 Y Y The subject will include experimental work in the laboratory, where the students will have to apply and test the theoretical concepts. Moreover, the students will developed the skills for manipulating biological samples and chemical according to safety and waste disposal standards. This activity will be compulsory but unrecoverable.
Practicum and practical activities report writing or preparation [OFF-SITE] Group Work E12 E13 E28 E29 G01 G03 T01 T03 T05 T06 T08 0.4 10 Y Y The students will deliver a practical note book with their results of lab sessions 1 & 2. This activity will be compulsory and unrecoverable.
Other on-site activities [ON-SITE] Assessment tests E01 E03 E29 T03 0.04 1 Y Y There will be a written test in which laboratory practices sessions will be evaluated.
Final test [ON-SITE] Assessment tests E01 E03 E04 E12 E28 G01 G03 T03 0.12 3 Y Y A final written test will evaluate the overall knowledge of the subject.
Progress test [ON-SITE] Assessment tests E01 E03 E04 E12 E28 T03 0.06 1.5 Y N The evaluation will included a progress test for Unit 1 and topics 2.1 and 2.2 of Unit 2.
Total: 6 150
Total credits of in-class work: 2.4 Total class time hours: 60
Total credits of out of class work: 3.6 Total hours of out of class work: 90

As: Assessable training activity
Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).

8. Evaluation criteria and Grading System
Evaluation System Continuous assessment Non-continuous evaluation * Description
Test 22.50% 25.00% This test will evaluate the laboratory sessions. This activity will be mandatory and recoverable. A minimum score of 4 points out of 10 in this test is required to make average with the rest of the marks.
Practicum and practical activities reports assessment 2.50% 0.00% A lab-book report of lab sessions 1 & 2 will be delivered within the indicated period of time. The delivery of this report is mandatory to pass the subject.
Final test 50.00% 75.00% Final written test to assess the knowledge acquired throughout the course. It will consist of two parts, one for the first six topics and one for the rest of the topics. The students who have passed the partial progress test (Unit 1 and topics 2.1 and 2.2 of Unit 2) will only have to be examined in the regular call of the subject corresponding to the rest of the items of Unit 2 and Unit 3. Those students who, despite having passed the partial progress test, want to take the complete final test, will have to renounce the grade obtained in the progress test. Therefore, the evaluation of the final test in the regular call will be 50%, if the partial progress test has been passed and 75%, if the partial progress test has not been passed. The final test is mandatory and recoverable. In order to consider and average the marks obtained in the other activities and pass the subject, it will be required to obtain a minimum grade of 4 out of 10 in the final test.
Progress Tests 25.00% 0.00% This test will consist on a written progress test about the contents of Unit 1 and topics 2.1 and 2.2 from Unit 2. To eliminate this part of the subject it will be required a minimun of 4 points out of 10. This partial progress test does not apply for the extraordinary call, which will include all the contents of the subject.
Total: 100.00% 100.00%  
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).

Evaluation criteria for the final exam:
  • Continuous assessment:
    To pass the subject, it will be necessary to obtain a minimum grade of 4 out of 10 in the final test and a minimun of 4 out of 10 in the evaluation test about laboratory sessions. The global mark of the subject will be calculated taking into account the percentages of previous table.
  • Non-continuous evaluation:
    To pass the subject, it will be necessary to obtain a minimum grade of 4 out of 10 in the final test and a minimun of 4 out of 10 in the evaluation test about laboratory sessions. The global mark of the subject will be calculated taking into account the percentages of previous table.

Specifications for the resit/retake exam:
The extraordinary or retake call consists in a final test including all the units, not considering the mark obtained in the partial progress test. The evaluation of the final test is 75% in the extraordinary call. To be able to pass the subject, it will be necessary to obtain a minimun grade of 4 out of 10 in the final test and a minimum of 4 out of 10 in the test about laboratory sessions. The final grade of the subject will be calculated taking into account the percentages of the above table. Those students who, having attended all the laboratory sessions, would not have passed the evaluation test of laboratory sessions in the ordinary call, will be able to repeat this evaluation test in the retake exam.
Specifications for the second resit / retake exam:
The evaluation of the final test is 75% and 25% for the laboratory exam. To be able to pass the subject, it will be necessary to obtain a minimun grade of 4 out of 10 in the final test and a minimum of 4 out of 10 in the test about laboratory sessions.
9. Assignments, course calendar and important dates
Not related to the syllabus/contents
Hours hours

10. Bibliography and Sources
Author(s) Title Book/Journal Citv Publishing house ISBN Year Description Link Catálogo biblioteca
 
 
 
 
 
Bishop, M.L. Clinical chemistry : principles, techniques, and correlation Lippincott Williams & Wilkins, 978-1-4511-1869-8 2013 Ficha de la biblioteca
Castaño López, Miguel Ángel Bioquímica clínica: de la patología al laboratorio 978-84-8473-617-2 2007 Ficha de la biblioteca
David Holme Analytical Biochemistry Prentice Hall 9780582294387 1998  
Delvin Thomas Bioquímica: libro de texto con aplicaciones clínicas Reverté 9788429172089 2008  
Fuentes Arderiu, X. Bioquímica clínica y patología molecular Reverté 84-291-1856-X 1998 Ficha de la biblioteca
García Espinosa, Benjamín Fundamentos y técnicas de análisis bioquímicos Algaida 978-84-7647-932-2 2009 Ficha de la biblioteca
García Segura, Juan Manuel Técnicas instrumentales de análisis en bioquímica Síntesis 978-84-7738-429-8 2008 Ficha de la biblioteca
Gaw, A. Bioquímica clínica : texto y atlas en color / Elsevier 978-84-9022-786-2 2014 Ficha de la biblioteca
González Hernández, Álvaro Principios de bioquímica clínica y patología molecular / Elsevier España 9788491133896 2019 Ficha de la biblioteca
González de Buitrago, José Manuel Técnicas y métodos de laboratorio clínico Elsevier-Masson 978-84-458-2029-2 2010 Ficha de la biblioteca
J. W. Baynes y M. H. Dominiczak Bioquímica médica Elsevier 978-84-8086-730-6 2011 Ficha de la biblioteca
Jesús Prieto Valtueña; José Ramón Yuste Interpretación de análisis y pruebas funcionales. Elsevier España 9788445820308 2015  
Kathleen Deska Pagana; Timothy J. Pagana Guía de pruebas diagnosticas y de laboratorio Elsevier España 9788480863582 2008  
Marshall, William J. Bioquímica clínica Elsevier 978-84-9022-115-0 2013 Ficha de la biblioteca
Ocon Navaza, Mª Carmen D' Fundamentos y técnicas de análisis bioquímico: principios de análisis instrumental Paraninfo 84-9732-159-6 2002 Ficha de la biblioteca
Pilar Roca Bioquímica, técnicas y métodos Hélice 84-921124-8-4 2003 Ficha de la biblioteca



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