1. General information
Course:
FUNDAMENTALS OF BIOCHEMISTRY
Code:
13307
Type:
BASIC
ECTS credits:
6
Degree:
341 - UNDERGRADUATE DEGREE PROGRAMME IN BIOCHEMISTRY
Academic year:
2021-22
Center:
501 - FACULTY OF ENVIRONMENTAL SCIENCES AND BIOCHEMISTRY
Group(s):
40
Year:
1
Duration:
C2
Main language:
Spanish
Second language:
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
OSCAR GOMEZ TORRES
- Group(s):
40
Building/Office
Department
Phone number
Email
Office hours
Edificio ICAM. Dcho. 32
QUÍMICA INORG., ORG., Y BIOQ.
926051783
oscar.gomez@uclm.es
Monday 10-11h
Lecturer:
MARIA RODRIGUEZ PEREZ
- Group(s):
40
Building/Office
Department
Phone number
Email
Office hours
Edif. 6. Dcho 11
QUÍMICA INORG., ORG., Y BIOQ.
5435
maria.rodriguezperez@uclm.es
Tuesday and Wednesday 10-12h
2. Pre-Requisites
Not established
3. Justification in the curriculum, relation to other subjects and to the profession
Not established
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| E01 | Express themselves correctly in basic biological, physical, chemical, mathematical and computer terms. |
| E09 | Be familiar with the different cell types (prokaryotes and eukaryotes) at the level of structure, physiology and biochemistry and be able to critically explain how their properties are adapted to their biological function. |
| E11 | To have an integrated vision of the cellular functioning of both the metabolism and the gene expression, being able to relate the activity of the different cellular compartments. |
| E15 | Experimentally determine the concentrations of metabolites, the kinetic and thermodynamic parameters and the control coefficients of the reactions of the intermediate metabolism. |
| E16 | Know how to design and execute the different steps of a protein and nucleic acid purification protocol of a biological sample, determining the yield and the final purity. |
| E19 | Understand the principles that determine the three-dimensional structure of biological molecules, macromolecules and supramolecular complexes and be able to explain the relationships between structure and function. |
| E21 | Understand the chemical and thermodynamic principles of biocatalysis and the role of enzymes and other biocatalysts in the functioning of cells and organisms. |
| G03 | Be able to collect and interpret relevant data, information and results, draw conclusions and issue reasoned reports on relevant social, scientific or ethical issues in connection with advances in Biochemistry and Molecular Biology. |
| T10 | Ability to self-learn and to obtain and manage bibliographic information, including Internet resources |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| To know the most relevant physiopathological alterations of the metabolism. | |
| Understand the structure and function of the main types of macromolecules. | |
| Know the fundamentals of enzymatic catalysis: enzymes and coenzymes. | |
| To know the basic mechanisms of metabolic regulation. | |
| Be able to describe the mechanism of ATP synthesis coupled to electronic transport. | |
| To know the participation of the different macromolecules in the structure of the cellular organelles. | |
| Understand the importance of the aqueous medium in biological systems. | |
| Understand and understand the metabolic compartmentalization and its role in the regulation of metabolism. | |
| To be able to make a general outline of the main catabolic and anabolic routes and to locate the main points of regulation. | |
| Know how to interpret a michaelian kinetics, calculate the parameters of Vmax and Km and distinguish these kinetics from the allosteric ones. | |
| To know the main anabolic and catabolic routes related to the metabolism of carbohydrates, lipids and proteins. | |
| Additional outcomes | |
| Description | |
6. Units / Contents
-
Unit 1: Molecular components of living beings.
-
Unit 1.1: Introduction to Biochemistry.
-
Unit 1.2: Proteins I
-
Unit 1.3: Proteins II.
-
Unit 1.4: Enzymes I
-
Unit 1.5: Enzymes II
-
Unit 1.6: Enzymes III
-
Unit 1.7: Structure and function of coenzymes.
-
Unit 1.8: Structure and function of carbohydrates and lipids.
-
-
Unit 2: Bioenergetics and Metabolism
-
Unit 2.1: Introduction to metabolism.
-
Unit 2.2: Carbohydrate metabolism.
-
Unit 2.3: Oxidative metabolism.
-
Unit 2.4: Gluconeogenesis and Metabolism of glycogen, glyoxylic acid cycle and glycogen metabolism.
-
Unit 2.5: Lipid metabolism.
-
Unit 2.6: Nitrogen metabolism.
-
-
Unit 3: Laboratory Sessions
-
Unit 3.1: Purification and protein quantification
-
Unit 3.2: Study of the enzymatic activity of catalase
-
Unit 3.3: Purification and quantification of nucleic acids. Electrophoresis in agarose gels
-
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Lectures | E01 E09 E11 E15 E16 E19 E21 | 1.6 | 40 | N | N | ||
| Laboratory practice or sessions [ON-SITE] | Practical or hands-on activities | E01 E15 E16 E21 G03 | 0.6 | 15 | Y | Y | ||
| Practicum and practical activities report writing or preparation [OFF-SITE] | Self-study | G03 | 0.08 | 2 | Y | Y | ||
| Other on-site activities [ON-SITE] | Assessment tests | E15 E16 E21 | 0.04 | 1 | Y | Y | ||
| Writing of reports or projects [OFF-SITE] | Group Work | G03 | 0.12 | 3 | Y | N | ||
| Writing of reports or projects [OFF-SITE] | Group tutoring sessions | E01 E09 E11 E19 E21 T10 | 0.04 | 1 | Y | N | ||
| Study and Exam Preparation [OFF-SITE] | Self-study | E01 E09 E11 E19 E21 T10 | 3.36 | 84 | N | N | ||
| Final test [ON-SITE] | Assessment tests | E01 E09 E11 E19 E21 | 0.16 | 4 | Y | Y | ||
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Practicum and practical activities reports assessment | 5.00% | 5.00% | evaluation of practicums. To pass the course it will be essential to obtain a minimum score of 4 points out of 10 in this test. |
| Test | 10.00% | 10.00% | practice test. To pass the course it will be essential to obtain a minimum score of 4 points out of 10 in this test. |
| Theoretical papers assessment | 5.00% | 0.00% | Assessment of reflective summaries |
| Final test | 80.00% | 85.00% | Final exam. To pass the course it will be essential to obtain a minimum score of 4 points out of 10 in this test. |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:The final mark for the course will be calculated taking into account the percentages in the table above. It will be an essential requirement to obtain a minimum of 4 in the practical exam and in the theory exam for the rest of the qualifications to be counted. The theory exam is ONLY passed with a 4. Therefore, in case of obtaining a mark lower than 4 in the practical or theory exam, the student will have to take the exam in the second retake exam. The subject will only be passed with a mark equal to or greater than 5 by adding all the assessable activities.
-
Non-continuous evaluation:The final mark for the course will be calculated taking into account the percentages in the table above. The theory exam is ONLY passed with a 4. Therefore, in the case of obtaining a mark lower than 4 in the practical or theory exam, the student will have to take the exam in the second retake exam. The subject will only be passed with a mark equal to or greater than 5 by adding all the assessable activities.
Specifications for the resit/retake exam:
The final mark for the course will be calculated taking into account the percentages described in the section corresponding to the ordinary call. Again, it will be an essential requirement to obtain a minimum of 4 in the practical exam and in the theory exam for the rest of the qualifications to be counted. The theory exam is ONLY passed with a 4. Therefore, in the event of obtaining a grade lower than 4 in the practice or theory exam, the student will fail the subject. The subject will only be passed with a mark equal to or greater than 5 by adding all the assessable activities.
Specifications for the second resit / retake exam:
To pass this exam there will only be a final test that will include concepts and learning developed both in theory and practical classes, and that will account for 100% of the grade. To take the exam, it will be essential that the laboratory practices have been carried out. In order to count the theory and practice mark, the minimum mark in both cases must be 4. The subject will only be passed with a mark equal to or greater than 5 by adding all the assessable activities.
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
| Unit 1 (de 3): Molecular components of living beings. | |
|---|---|
| Group 300: | |
| Initial date: 28/01/2020 | End date: 8/05/2020 |
| Group 40: | |
| Initial date: 28/01/2020 | End date: 8/05/2020 |
| Unit 2 (de 3): Bioenergetics and Metabolism | |
|---|---|
| Group 40: | |
| Initial date: 28/01/2020 | End date: 8/05/2020 |
| Group 300: | |
| Initial date: 28/01/2020 | End date: 8/05/2020 |
| Unit 3 (de 3): Laboratory Sessions | |
|---|---|
| Group 40: | |
| Initial date: 28/01/2020 | End date: 8/05/2020 |
| Group 300: | |
| Initial date: 28/01/2020 | End date: 8/05/2020 |
10. Bibliography and Sources
