1. General information
Course:
GENETICS AND EVOLUTION
Code:
13305
Type:
CORE COURSE
ECTS credits:
6
Degree:
341 - UNDERGRADUATE DEGREE PROGRAMME IN BIOCHEMISTRY
Academic year:
2021-22
Center:
501 - FACULTY OF ENVIRONMENTAL SCIENCES AND BIOCHEMISTRY
Group(s):
40
Year:
1
Duration:
C2
Main language:
Spanish
Second language:
English
Use of additional languages:
English Friendly:
Y
Web site:
Bilingual:
N
Lecturer:
MARTA CARMEN GUADAMILLAS MORA
- Group(s):
40
Building/Office
Department
Phone number
Email
Office hours
Sabatini/017.2
CIENCIA Y TECNOLOGÍA AGROFORESTAL Y GENÉTICA
Marta.Guadamillas@uclm.es
Tuesday,wednesday, friday. 12:00-14.00h
Lecturer:
ISABEL MARTINEZ ARGUDO
- Group(s):
40
Building/Office
Department
Phone number
Email
Office hours
Sabatini/01
CIENCIA Y TECNOLOGÍA AGROFORESTAL Y GENÉTICA
925 268 800
isabel.margudo@uclm.es
Monday, tuesday, wednesday 12.00-14.00h
2. Pre-Requisites
Not established
3. Justification in the curriculum, relation to other subjects and to the profession
The course will introduce basic genetics concepts and will show the central role of genetics in biology.
The content is related with other courses as: Gene expresion (year 2), Genetic Engineering (year 3) and Molecular Pathology (year 3).
Genetic knowledge is basic to professional areas as basic research and molecular diagnosis of genetic human diseases.
4. Degree competences achieved in this course
| Course competences | |
|---|---|
| Code | Description |
| E01 | Express themselves correctly in basic biological, physical, chemical, mathematical and computer terms. |
| E02 | Work properly and quality driven in a chemical, biological and biochemical laboratory, including safety, handling and disposal of waste and keeping a record of activities. |
| E05 | Acquire, develop and apply the main techniques for the preparation and observation of biological samples and identify and describe the different organs, tissues and animal and plant cells in the different types of preparations. |
| E07 | To know the structure of genes and the mechanisms of DNA replication, recombination and repair in the context of the functioning of cells and organisms, as well as the basis of heredity and genetic and epigenetic variation between individuals. |
| E08 | Analyze and interpret results derived from the realization of animal and/or plant karyotypes, chromosome bands and practical genetic problems. |
| E09 | Be familiar with the different cell types (prokaryotes and eukaryotes) at the level of structure, physiology and biochemistry and be able to critically explain how their properties are adapted to their biological function. |
| E12 | Have the numerical and computational skills to apply mathematical procedures for data analysis. |
| G01 | To possess and understand the knowledge in the area of Biochemistry and Molecular Biology at a level that, based on advanced textbooks, also includes cutting-edge aspects of relevance in the discipline |
| G02 | To know how to apply the knowledge of Biochemistry and Molecular Biology to professional practice and to possess the necessary intellectual skills and abilities for this practice, including the capacity for: information management, analysis and synthesis, problem solving, organization and planning and generation of new ideas. |
| G03 | Be able to collect and interpret relevant data, information and results, draw conclusions and issue reasoned reports on relevant social, scientific or ethical issues in connection with advances in Biochemistry and Molecular Biology. |
| G04 | To know how to transmit information, ideas, problems and solutions in the field of Biochemistry and Molecular Biology to a specialized and non-specialized public. |
| T01 | Proficiency in a second foreign language, preferably English, at level B1 of the Common European Framework of Reference for Languages |
| T02 | User-level knowledge of Information and Communication Technologies (ICT). |
| T03 | A correct oral and written communication |
| T05 | Organizational and planning skills |
5. Objectives or Learning Outcomes
| Course learning outcomes | |
|---|---|
| Description | |
| To know the applications of genetics to human biology. | |
| Master the basic terminology of genetics. | |
| To know the mechanisms of modification of the genetic material. | |
| To know the relationship between structure and function of nucleic acids | |
| Understand clearly the mechanisms of heredity | |
| Understand the fundamental role of genetics in the evolution of living beings. | |
| To know the structural bases of the interactions between macromolecules | |
| Be able to correctly express the concepts and principles of heredity | |
| Understanding how a genetic analysis is performed | |
| Additional outcomes | |
| Not established. |
6. Units / Contents
-
Unit 1: Introduction
-
Unit 1.1: Genetics as a science
-
-
Unit 2: Inheritance
-
Unit 2.1: Chromosomal basis of inheritance
-
Unit 2.2: Sex determination. Sex linked inheritance
-
Unit 2.3: Inheritance in humans
-
Unit 2.4: Gene interaction
-
Unit 2.5: Environment and genes
-
Unit 2.6: Linkage and recombination in eukaryotes
-
-
Unit 3: Molecular basis og inheritance
-
Unit 3.1: Nature and structure of the hereditary material
-
Unit 3.2: Organization and replication of genetic material
-
Unit 3.3: Molecular biology of gene function. Transcription. Genetic code and translation
-
Unit 3.4: Gene mutation. Genetic analysis
-
Unit 3.5: Chromosome mutation
-
-
Unit 4: Population genetics and evolution
-
Unit 4.1: Quantitative genetics. Heritability
-
Unit 4.2: Genetic structure of populations
-
Unit 4.3: Changes in alelic frequencies. Mutation, migration, genetic drift and selection
-
Unit 4.4: Speciation and evolution. Molecular evolution
-
-
Unit 5: Practical contents
-
Unit 5.1: Genetic mapping. Sex linkage inherintace.
-
Unit 5.2: Inheritance in humans
-
Unit 5.3: Electrophoresis of DNA
-
Unit 5.4: Epistasis
-
7. Activities, Units/Modules and Methodology
| Training Activity | Methodology | Related Competences (only degrees before RD 822/2021) | ECTS | Hours | As | Com | Description | |
| Class Attendance (theory) [ON-SITE] | Lectures | E07 E08 G01 | 1.32 | 33 | N | N | ||
| Problem solving and/or case studies [ON-SITE] | Combination of methods | E01 E08 E09 E12 G03 G04 | 0.32 | 8 | Y | N | ||
| Other off-site activity [OFF-SITE] | Project/Problem Based Learning (PBL) | E01 E08 E12 G03 | 0.6 | 15 | Y | N | ||
| Laboratory practice or sessions [ON-SITE] | Practical or hands-on activities | E01 E02 E05 E08 E09 E12 G02 G03 | 0.6 | 15 | Y | Y | ||
| Progress test [ON-SITE] | Assessment tests | E01 E07 E12 G01 G03 | 0.04 | 1 | Y | N | ||
| Final test [ON-SITE] | Assessment tests | E01 E02 E05 E07 E08 E09 E12 G01 G02 G03 G04 | 0.12 | 3 | Y | Y | ||
| Study and Exam Preparation [OFF-SITE] | Self-study | E01 E07 E08 E09 E12 G01 | 3 | 75 | N | N | ||
| Total: | 6 | 150 | ||||||
| Total credits of in-class work: 2.4 | Total class time hours: 60 | |||||||
| Total credits of out of class work: 3.6 | Total hours of out of class work: 90 | |||||||
As: Assessable training activity Com: Training activity of compulsory overcoming (It will be essential to overcome both continuous and non-continuous assessment).
8. Evaluation criteria and Grading System
| Evaluation System | Continuous assessment | Non-continuous evaluation * | Description |
| Laboratory sessions | 15.00% | 15.00% | Assitence is compulsory. Evaluation would be through a cuestionaire. It is compulsoty to obtain a 4/10 |
| Assessment of problem solving and/or case studies | 10.00% | 0.00% | Not mandatory. |
| Progress Tests | 10.00% | 0.00% | Test for evaluation of Topic 2. |
| Final test | 65.00% | 85.00% | It is mandatory to obtain a score> 4 over 10 in the final exam to add all other evaluable parts in the percentages shown in the table. |
| Total: | 100.00% | 100.00% |
According to art. 4 of the UCLM Student Evaluation Regulations, it must be provided to students who cannot regularly attend face-to-face training activities the passing of the subject, having the right (art. 12.2) to be globally graded, in 2 annual calls per subject , an ordinary and an extraordinary one (evaluating 100% of the competences).
Evaluation criteria for the final exam:
-
Continuous assessment:It is mandatory to obtain a score> 4 over 10 in the final exam to add all other evaluable parts in the percentages shown in the table.
It is compulsory to pass the laboratory sessions and obtain a score of 4/10 in the laboratory test to pass the course.
The subject will be considered as passed if a minimum overall weighted score of 5 out of 10 is obtained. -
Non-continuous evaluation:Criteria will be the same.
At the beginning of the course, students should tell the professor if they wish to be evaluate non continuously
Specifications for the resit/retake exam:
For the retake exam only the the laboratory evaluation test can be re-taken, applying for the other sections the marks obtained during the duration of the course.
Specifications for the second resit / retake exam:
To pass this examination there will be only a final exam that will represent 100% of the mark, provided that the laboratory sessions have been performed and passed.
9. Assignments, course calendar and important dates
| Not related to the syllabus/contents | |
|---|---|
| Hours | hours |
| Other off-site activity [AUTÓNOMA][Project/Problem Based Learning (PBL)] | 15 |
| Progress test [PRESENCIAL][Assessment tests] | 1 |
| Final test [PRESENCIAL][Assessment tests] | 3 |
| Study and Exam Preparation [AUTÓNOMA][Self-study] | 75 |
| Unit 1 (de 5): Introduction | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 1 |
| Group 40: | |
| Initial date: 31-01-2022 | End date: |
| Unit 2 (de 5): Inheritance | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 14 |
| Problem solving and/or case studies [PRESENCIAL][Combination of methods] | 3 |
| Group 40: | |
| Initial date: 02-02-2022 | End date: |
| Unit 3 (de 5): Molecular basis og inheritance | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 10 |
| Problem solving and/or case studies [PRESENCIAL][Combination of methods] | 3 |
| Group 40: | |
| Initial date: 14-03-2022 | End date: |
| Unit 4 (de 5): Population genetics and evolution | |
|---|---|
| Activities | Hours |
| Class Attendance (theory) [PRESENCIAL][Lectures] | 8 |
| Problem solving and/or case studies [PRESENCIAL][Combination of methods] | 2 |
| Group 40: | |
| Initial date: 18-04-2022 | End date: |
| Unit 5 (de 5): Practical contents | |
|---|---|
| Activities | Hours |
| Laboratory practice or sessions [PRESENCIAL][Practical or hands-on activities] | 15 |
| Group 40: | |
| Initial date: 28-02-2022 | End date: 25-03-2022 |
| Global activity | |
|---|---|
| Activities | hours |
10. Bibliography and Sources
